Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 923313..923810 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag QQ971_RS04365 Protein ID WP_001173343.1
Coordinates 923637..923810 (+) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag QQ971_RS04360 Protein ID WP_000398619.1
Coordinates 923313..923609 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS04340 (920044) 920044..920763 - 720 WP_000611288.1 two-component system response regulator DcuR -
QQ971_RS04345 (920760) 920760..922391 - 1632 WP_001216461.1 sensor histidine kinase -
QQ971_RS04350 (922572) 922572..922802 + 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
QQ971_RS04355 (922814) 922814..923086 + 273 WP_000405647.1 GNAT family N-acetyltransferase -
QQ971_RS04360 (923313) 923313..923609 + 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
QQ971_RS04365 (923637) 923637..923810 + 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
QQ971_RS04370 (923929) 923929..925446 - 1518 WP_001295074.1 lysine--tRNA ligase -
QQ971_RS04375 (925683) 925683..927140 - 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T283688 WP_001173343.1 NZ_CP127252:923637-923810 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT283688 WP_000398619.1 NZ_CP127252:923313-923609 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
PDB 2LLZ
AlphaFold DB A0A7U9QBH6

References