Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 186041..186627 Replicon chromosome
Accession NZ_CP127252
Organism Escherichia coli strain C41

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag QQ971_RS00995 Protein ID WP_042014162.1
Coordinates 186397..186627 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag QQ971_RS00990 Protein ID WP_000593555.1
Coordinates 186041..186400 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ971_RS00965 (182173) 182173..183117 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
QQ971_RS00970 (183114) 183114..183947 + 834 WP_001008968.1 nickel ABC transporter permease subunit NikC -
QQ971_RS00975 (183947) 183947..184711 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
QQ971_RS00980 (184708) 184708..185514 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
QQ971_RS00985 (185520) 185520..185921 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
QQ971_RS00990 (186041) 186041..186400 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQ971_RS00995 (186397) 186397..186627 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
QQ971_RS01000 (186731) 186731..187855 - 1125 WP_089625056.1 ABC transporter permease -
QQ971_RS01005 (187855) 187855..190590 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T283686 WP_042014162.1 NZ_CP127252:c186627-186397 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT283686 WP_000593555.1 NZ_CP127252:c186400-186041 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References