Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4045640..4046271 Replicon chromosome
Accession NZ_CP127244
Organism Salinicola sp. JS01

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QO259_RS18470 Protein ID WP_207036655.1
Coordinates 4046089..4046271 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QO259_RS18465 Protein ID WP_207036657.1
Coordinates 4045640..4046050 (-) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QO259_RS18445 (QO259_18445) 4041142..4041912 + 771 WP_285951110.1 SDR family NAD(P)-dependent oxidoreductase -
QO259_RS18450 (QO259_18450) 4041958..4043148 + 1191 WP_285951111.1 acetyl-CoA C-acyltransferase -
QO259_RS18455 (QO259_18455) 4043204..4044949 + 1746 WP_285951112.1 AMP-binding protein -
QO259_RS18460 (QO259_18460) 4044974..4045399 - 426 WP_285951113.1 hotdog fold thioesterase -
QO259_RS18465 (QO259_18465) 4045640..4046050 - 411 WP_207036657.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QO259_RS18470 (QO259_18470) 4046089..4046271 - 183 WP_207036655.1 type II toxin-antitoxin system HicA family toxin Toxin
QO259_RS18475 (QO259_18475) 4046998..4048395 + 1398 WP_285951114.1 GntP family permease -
QO259_RS18480 (QO259_18480) 4048400..4049107 + 708 WP_285951115.1 AMP-binding protein -
QO259_RS18485 (QO259_18485) 4049013..4050095 + 1083 WP_285952801.1 AMP-binding protein -
QO259_RS18490 (QO259_18490) 4050127..4050594 + 468 WP_285951116.1 MaoC/PaaZ C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6715.92 Da        Isoelectric Point: 11.0703

>T283684 WP_207036655.1 NZ_CP127244:c4046271-4046089 [Salinicola sp. JS01]
VKSRDLIKELEADGWVLDRIRGSHHVFKHPTKPGAVPVPHPKKDMKIGTINAIRKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14864.75 Da        Isoelectric Point: 4.9122

>AT283684 WP_207036657.1 NZ_CP127244:c4046050-4045640 [Salinicola sp. JS01]
MQYPIAIDWGDDTHATGIVFPDIPGAITAGDSVAHAYEMAVEVAHIQLEELVSAGQPIPKPGSIEQHRQNPDFEGWGWGL
VEIDVTPYLGKTEKVNVTLPGTLVKRIDDYVSLHGIKSRSAFLASAALHELEHRSR

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References