Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 148219..148862 Replicon plasmid pKPC2_130128
Accession NZ_CP127236
Organism Klebsiella pneumoniae strain 130128

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag QRA17_RS27910 Protein ID WP_001044770.1
Coordinates 148219..148635 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag QRA17_RS27915 Protein ID WP_001261282.1
Coordinates 148632..148862 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA17_RS27890 (144322) 144322..144594 - 273 Protein_189 transposase -
QRA17_RS27900 (145576) 145576..146598 - 1023 WP_000361404.1 helicase UvrD -
QRA17_RS27905 (146583) 146583..148145 - 1563 WP_004206609.1 AAA family ATPase -
QRA17_RS27910 (148219) 148219..148635 - 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
QRA17_RS27915 (148632) 148632..148862 - 231 WP_001261282.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QRA17_RS27920 (148819) 148819..149280 + 462 WP_014343465.1 hypothetical protein -
QRA17_RS27925 (149441) 149441..150385 + 945 WP_011977810.1 hypothetical protein -
QRA17_RS27930 (150422) 150422..150814 + 393 WP_011977811.1 hypothetical protein -
QRA17_RS27935 (150872) 150872..151393 + 522 WP_013214008.1 hypothetical protein -
QRA17_RS27940 (151439) 151439..151642 + 204 WP_011977813.1 hypothetical protein -
QRA17_RS27945 (151672) 151672..152676 + 1005 WP_011977814.1 hypothetical protein -
QRA17_RS27950 (152860) 152860..153639 + 780 WP_013214009.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid rmtB / blaTEM-1B / blaCTX-M-65 / blaKPC-2 - 1..154719 154719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T283676 WP_001044770.1 NZ_CP127236:c148635-148219 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT283676 WP_001261282.1 NZ_CP127236:c148862-148632 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References