Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1297797..1299620 Replicon chromosome
Accession NC_018672
Organism Burkholderia phenoliruptrix BR3459a

Toxin (Protein)


Gene name doc Uniprot ID A0A6J5K407
Locus tag BUPH_RS23995 Protein ID WP_013591222.1
Coordinates 1298718..1299620 (-) Length 301 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID K0DVP5
Locus tag BUPH_RS23990 Protein ID WP_013591221.1
Coordinates 1297797..1298717 (-) Length 307 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BUPH_RS23970 1292961..1294451 - 1491 WP_013591217.1 aldehyde dehydrogenase -
BUPH_RS23975 1294520..1295350 - 831 WP_014972620.1 aspartate dehydrogenase -
BUPH_RS23980 1295343..1297001 - 1659 WP_014972621.1 thiamine pyrophosphate-binding protein -
BUPH_RS23985 1296994..1297800 - 807 WP_013591220.1 SDR family oxidoreductase -
BUPH_RS23990 1297797..1298717 - 921 WP_013591221.1 IclR family transcriptional regulator Antitoxin
BUPH_RS23995 1298718..1299620 - 903 WP_013591222.1 alpha/beta fold hydrolase Toxin
BUPH_RS24000 1299657..1300184 - 528 WP_013591223.1 cupin domain-containing protein -
BUPH_RS24005 1300211..1300978 - 768 WP_013591224.1 SDR family oxidoreductase -
BUPH_RS24010 1300971..1302074 - 1104 WP_014972623.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BUPH_RS24015 1302124..1302435 - 312 WP_013591225.1 hypothetical protein -
BUPH_RS24020 1302437..1302751 - 315 WP_013591226.1 non-heme iron oxygenase ferredoxin subunit -
BUPH_RS24025 1303192..1304265 + 1074 WP_013591227.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-282)

Antitoxin

Transcription regulator IclR, N-terminal

(41-89)


Sequences

Toxin        


Download         Length: 301 a.a.        Molecular weight: 31336.42 Da        Isoelectric Point: 7.9564

>T28366 WP_013591222.1 NC_018672:c1299620-1298718 [Paraburkholderia phenoliruptrix BR3459a]
MSATALTDANATLEARLARFPARQIALAQRRTLSYREANGAEDAARAVDNALPLVLLHGIGSGAASWVQQLESLGARRRV
LAWDAPGYGESTPVAAASPAASDYASVLGEWLAALHIERCVLVGHSLGAIIAGAFAASHPKRVAGLLLLSPAGGYGASPA
QVREARRDQRLAMLNELGPQGLADTRSANMLSEQASDEARAWVRWNMSRVIPHGYAQATHLLANADLAADLARFKGRVNV
AVGADDTITPPAACERLALAAGTPLQVVPRAGHAGYIEADAAYNAIIDTFSRASAGPRSQ

Download         Length: 903 bp

>T28366 NC_018672:c1299620-1298718 [Paraburkholderia phenoliruptrix BR3459a]
ATGTCCGCCACCGCTCTCACCGATGCGAACGCCACGCTCGAAGCACGCCTTGCACGCTTTCCTGCCCGGCAGATCGCGCT
CGCACAGCGACGCACGCTGAGCTATCGCGAAGCGAATGGCGCCGAAGATGCCGCTCGCGCCGTGGATAACGCGTTGCCGC
TGGTGCTGCTGCACGGTATCGGTTCGGGCGCGGCTTCGTGGGTGCAGCAATTGGAGTCGCTGGGCGCACGCCGTCGCGTG
CTGGCATGGGACGCGCCGGGTTATGGCGAATCGACGCCGGTTGCGGCGGCGTCGCCCGCGGCAAGCGATTACGCAAGCGT
GCTCGGTGAATGGCTCGCCGCGCTTCACATCGAACGCTGCGTGTTGGTGGGGCATTCGCTTGGCGCAATCATCGCTGGGG
CGTTTGCCGCGAGCCATCCAAAGCGTGTGGCAGGCCTGCTGCTGCTCTCGCCCGCCGGCGGCTACGGCGCGTCACCCGCG
CAAGTGCGCGAAGCCAGGCGCGACCAGCGTCTTGCGATGCTGAACGAGCTCGGCCCGCAAGGCCTCGCCGACACACGCAG
CGCCAATATGTTGTCTGAGCAGGCGAGCGACGAAGCACGCGCATGGGTGCGTTGGAACATGTCGCGCGTGATTCCCCATG
GCTACGCGCAGGCCACGCATCTGCTGGCCAACGCGGATCTCGCCGCCGATCTCGCGCGCTTCAAGGGCCGCGTCAACGTG
GCAGTCGGCGCCGACGACACCATCACGCCCCCCGCCGCCTGCGAGCGGCTCGCACTCGCGGCCGGCACGCCGCTGCAGGT
GGTGCCGCGCGCGGGGCACGCCGGCTATATCGAAGCCGACGCCGCGTACAACGCGATCATCGACACGTTCAGCCGCGCAA
GCGCCGGACCACGGAGCCAATAA

Antitoxin


Download         Length: 307 a.a.        Molecular weight: 34101.52 Da        Isoelectric Point: 6.6655

>AT28366 WP_013591221.1 NC_018672:c1298717-1297797 [Paraburkholderia phenoliruptrix BR3459a]
MTPETLNERDAEDERNNEHNNEQNGNHNDSGGESSYRVPGLERGLKILTEFSPREPVLGAPELSRRLKIPRTTVFRLLQT
LESLGFLERADKDRNYRLGVAVLRLGFEYLSSLELTDLGLPIIEALRDDTGLTTHIVIRDGRDVVFVAKAQSHAPIFSSV
KVNVGTRLPAYATTHGQVLMGDMTLDELKKLYPEPELERFTRQTPATVVELYERIRDDARRGFAISESSFERGISVVSAP
VRNDTGRIVAVITTTIPRQEIDASLLDSGLVDKVRRAAGELSQRLNYRPGNASNSGSKYMKALGLK

Download         Length: 921 bp

>AT28366 NC_018672:c1298717-1297797 [Paraburkholderia phenoliruptrix BR3459a]
ATGACGCCCGAGACCCTCAATGAGCGCGACGCGGAAGACGAGCGCAACAACGAGCACAACAACGAGCAAAACGGCAACCA
CAACGACAGCGGTGGCGAATCGAGCTATCGCGTGCCGGGTCTGGAGCGCGGTCTGAAGATACTGACCGAGTTTTCGCCGC
GTGAGCCCGTTCTCGGCGCCCCGGAATTATCGAGGCGCCTGAAGATTCCTCGCACGACGGTTTTCCGTTTGCTGCAAACG
CTCGAGTCGCTGGGCTTTCTCGAGCGCGCGGACAAGGACCGCAACTATCGGCTCGGCGTGGCCGTGCTGCGCCTCGGCTT
CGAATATCTAAGCTCGCTGGAGTTGACCGACCTCGGCTTGCCGATCATCGAAGCACTGCGCGACGACACCGGCCTCACCA
CGCACATTGTGATTCGCGATGGACGCGACGTCGTCTTTGTCGCGAAGGCGCAAAGCCATGCACCCATTTTCAGTTCCGTG
AAGGTCAACGTCGGTACGCGCTTGCCCGCGTATGCGACCACGCACGGCCAGGTGCTGATGGGCGACATGACGCTCGACGA
ATTGAAAAAGCTCTATCCGGAACCGGAACTGGAGCGCTTCACACGGCAAACGCCTGCCACGGTAGTTGAACTCTACGAAC
GGATCCGCGACGACGCGCGGCGCGGTTTTGCGATCAGCGAGTCGTCGTTCGAGCGCGGCATTTCGGTGGTGAGCGCGCCG
GTGCGCAACGACACGGGGCGCATCGTCGCCGTGATCACGACGACGATTCCGCGCCAGGAAATCGACGCGTCGCTGCTCGA
CAGCGGCCTCGTCGACAAGGTGCGCCGCGCGGCCGGCGAACTCTCGCAGCGGCTCAATTACCGTCCCGGCAATGCGTCGA
ATTCCGGCAGCAAATACATGAAGGCACTGGGGCTCAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6J5K407

Antitoxin

Source ID Structure
AlphaFold DB K0DVP5

References