Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 856094..856748 Replicon chromosome
Accession NZ_CP127235
Organism Klebsiella pneumoniae strain 130128

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag QRA17_RS04320 Protein ID WP_004144731.1
Coordinates 856341..856748 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QRA17_RS04315 Protein ID WP_002916312.1
Coordinates 856094..856360 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA17_RS04290 (QRA17_04290) 851250..852683 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QRA17_RS04295 (QRA17_04295) 852802..853530 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QRA17_RS04300 (QRA17_04300) 853580..853891 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QRA17_RS04305 (QRA17_04305) 854055..854714 + 660 WP_002916317.1 hemolysin III family protein -
QRA17_RS04310 (QRA17_04310) 854865..855848 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QRA17_RS04315 (QRA17_04315) 856094..856360 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QRA17_RS04320 (QRA17_04320) 856341..856748 + 408 WP_004144731.1 protein YgfX Toxin
QRA17_RS04325 (QRA17_04325) 856755..857276 - 522 WP_002916308.1 flavodoxin FldB -
QRA17_RS04330 (QRA17_04330) 857377..858273 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QRA17_RS04335 (QRA17_04335) 858296..859009 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRA17_RS04340 (QRA17_04340) 859015..860748 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T283658 WP_004144731.1 NZ_CP127235:856341-856748 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT283658 WP_002916312.1 NZ_CP127235:856094-856360 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References