Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 720589..721364 Replicon chromosome
Accession NZ_CP127235
Organism Klebsiella pneumoniae strain 130128

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QRA17_RS03600 Protein ID WP_004150910.1
Coordinates 720879..721364 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QRA17_RS03595 Protein ID WP_004150912.1
Coordinates 720589..720882 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA17_RS03580 (QRA17_03580) 716965..719296 + 2332 Protein_703 YgiQ family radical SAM protein -
QRA17_RS03585 (QRA17_03585) 719296..719529 + 234 Protein_704 GNAT family N-acetyltransferase -
QRA17_RS03595 (QRA17_03595) 720589..720882 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QRA17_RS03600 (QRA17_03600) 720879..721364 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QRA17_RS03605 (QRA17_03605) 722068..722661 + 594 WP_004188553.1 hypothetical protein -
QRA17_RS03610 (QRA17_03610) 722758..722974 + 217 Protein_709 transposase -
QRA17_RS03615 (QRA17_03615) 723580..724452 + 873 WP_004188557.1 ParA family protein -
QRA17_RS03620 (QRA17_03620) 724452..724835 + 384 WP_004150906.1 hypothetical protein -
QRA17_RS03625 (QRA17_03625) 724828..726195 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 719546..722910 3364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T283657 WP_004150910.1 NZ_CP127235:720879-721364 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT283657 WP_004150912.1 NZ_CP127235:720589-720882 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References