Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 620..1094 Replicon plasmid p3_130119
Accession NZ_CP127234
Organism Klebsiella pneumoniae strain 130119

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag QRA14_RS29380 Protein ID WP_004197762.1
Coordinates 828..1094 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag QRA14_RS29375 Protein ID WP_000879771.1
Coordinates 620..844 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA14_RS29370 (QRA14_29375) 329..457 - 129 WP_000523570.1 hypothetical protein -
QRA14_RS29375 (QRA14_29380) 620..844 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
QRA14_RS29380 (QRA14_29385) 828..1094 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRA14_RS29385 (QRA14_29390) 1164..1514 - 351 WP_004197756.1 hypothetical protein -
QRA14_RS29390 (QRA14_29395) 1580..2125 - 546 WP_023317533.1 hypothetical protein -
QRA14_RS29395 (QRA14_29400) 2151..2477 - 327 WP_050516389.1 hypothetical protein -
QRA14_RS29400 (QRA14_29405) 3633..3809 + 177 WP_004197757.1 hypothetical protein -
QRA14_RS29405 (QRA14_29410) 3799..4143 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
QRA14_RS29410 (QRA14_29415) 4352..4786 + 435 Protein_8 relaxase/mobilization nuclease domain-containing protein -
QRA14_RS29415 (QRA14_29420) 4821..5330 + 510 WP_032433972.1 MbeB family mobilization protein -
QRA14_RS29420 (QRA14_29425) 5337..5549 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T283654 WP_004197762.1 NZ_CP127234:828-1094 [Klebsiella pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT283654 WP_000879771.1 NZ_CP127234:620-844 [Klebsiella pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References