Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3493..4073 Replicon plasmid p2_130119
Accession NZ_CP127233
Organism Klebsiella pneumoniae strain 130119

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag QRA14_RS29330 Protein ID WP_071177730.1
Coordinates 3493..3807 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QRA14_RS29335 Protein ID WP_000093040.1
Coordinates 3795..4073 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA14_RS29310 (QRA14_29315) 1401..2132 + 732 WP_071177728.1 MobC family replication-relaxation protein -
QRA14_RS29315 (QRA14_29320) 2139..2669 + 531 WP_071177729.1 hypothetical protein -
QRA14_RS29320 (QRA14_29325) 2696..2875 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
QRA14_RS29325 (QRA14_29330) 2901..3329 - 429 WP_001140599.1 hypothetical protein -
QRA14_RS29330 (QRA14_29335) 3493..3807 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRA14_RS29335 (QRA14_29340) 3795..4073 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QRA14_RS29340 (QRA14_29345) 4248..4613 - 366 WP_072354022.1 TonB family protein -
QRA14_RS29345 (QRA14_29350) 4610..4981 - 372 WP_001237044.1 cell envelope integrity protein TolA -
QRA14_RS29350 (QRA14_29355) 5255..5500 - 246 WP_032440458.1 hypothetical protein -
QRA14_RS29355 (QRA14_29360) 5827..7512 + 1686 WP_032440457.1 colicin-like bacteriocin tRNase domain-containing protein -
QRA14_RS29360 (QRA14_29365) 7522..7779 + 258 WP_032440455.1 colicin E3-like toxin immunity protein -
QRA14_RS29365 (QRA14_29370) 7864..8013 + 150 WP_032440454.1 colicin release lysis protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..10060 10060


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T283653 WP_071177730.1 NZ_CP127233:c3807-3493 [Klebsiella pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT283653 WP_000093040.1 NZ_CP127233:c4073-3795 [Klebsiella pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References