Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5052427..5054015 Replicon chromosome
Accession NZ_CP127229
Organism Klebsiella pneumoniae strain 130119

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag QRA14_RS24745 Protein ID WP_004199851.1
Coordinates 5052427..5053749 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QRA14_RS24750 Protein ID WP_002904790.1
Coordinates 5053749..5054015 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA14_RS24730 (QRA14_24735) 5047492..5049993 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
QRA14_RS24735 (QRA14_24740) 5049981..5050985 + 1005 WP_004199852.1 fimbrial protein -
QRA14_RS24740 (QRA14_24745) 5051118..5052410 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QRA14_RS24745 (QRA14_24750) 5052427..5053749 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
QRA14_RS24750 (QRA14_24755) 5053749..5054015 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QRA14_RS24755 (QRA14_24760) 5054281..5054607 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QRA14_RS24760 (QRA14_24765) 5054604..5055104 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QRA14_RS24765 (QRA14_24770) 5055082..5056461 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
QRA14_RS24770 (QRA14_24775) 5056807..5057961 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QRA14_RS24775 (QRA14_24780) 5057942..5058865 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T283645 WP_004199851.1 NZ_CP127229:c5053749-5052427 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT283645 WP_002904790.1 NZ_CP127229:c5054015-5053749 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References