Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3179223..3179877 Replicon chromosome
Accession NZ_CP127229
Organism Klebsiella pneumoniae strain 130119

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag QRA14_RS15550 Protein ID WP_004144731.1
Coordinates 3179470..3179877 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QRA14_RS15545 Protein ID WP_002916312.1
Coordinates 3179223..3179489 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA14_RS15520 (QRA14_15520) 3174379..3175812 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QRA14_RS15525 (QRA14_15525) 3175931..3176659 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QRA14_RS15530 (QRA14_15530) 3176709..3177020 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QRA14_RS15535 (QRA14_15535) 3177184..3177843 + 660 WP_002916317.1 hemolysin III family protein -
QRA14_RS15540 (QRA14_15540) 3177994..3178977 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QRA14_RS15545 (QRA14_15545) 3179223..3179489 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QRA14_RS15550 (QRA14_15550) 3179470..3179877 + 408 WP_004144731.1 protein YgfX Toxin
QRA14_RS15555 (QRA14_15555) 3179884..3180405 - 522 WP_002916308.1 flavodoxin FldB -
QRA14_RS15560 (QRA14_15560) 3180506..3181402 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QRA14_RS15565 (QRA14_15565) 3181425..3182138 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QRA14_RS15570 (QRA14_15570) 3182144..3183877 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T283640 WP_004144731.1 NZ_CP127229:3179470-3179877 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT283640 WP_002916312.1 NZ_CP127229:3179223-3179489 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References