Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2227707..2228332 Replicon chromosome
Accession NZ_CP127229
Organism Klebsiella pneumoniae strain 130119

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QRA14_RS10775 Protein ID WP_002882817.1
Coordinates 2227707..2228090 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QRA14_RS10780 Protein ID WP_004150355.1
Coordinates 2228090..2228332 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA14_RS10760 (QRA14_10760) 2225073..2225975 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QRA14_RS10765 (QRA14_10765) 2225972..2226607 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QRA14_RS10770 (QRA14_10770) 2226604..2227533 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QRA14_RS10775 (QRA14_10775) 2227707..2228090 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QRA14_RS10780 (QRA14_10780) 2228090..2228332 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QRA14_RS10785 (QRA14_10785) 2228537..2229454 + 918 WP_002882812.1 alpha/beta hydrolase -
QRA14_RS10790 (QRA14_10790) 2229468..2230409 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QRA14_RS10795 (QRA14_10795) 2230454..2230891 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QRA14_RS10800 (QRA14_10800) 2230888..2231748 - 861 WP_002882807.1 virulence factor BrkB family protein -
QRA14_RS10805 (QRA14_10805) 2231742..2232341 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T283637 WP_002882817.1 NZ_CP127229:c2228090-2227707 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT283637 WP_004150355.1 NZ_CP127229:c2228332-2228090 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References