Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 1903622..1905303 | Replicon | chromosome |
Accession | NZ_CP127229 | ||
Organism | Klebsiella pneumoniae strain 130119 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | W8V1Q6 |
Locus tag | QRA14_RS09270 | Protein ID | WP_002885155.1 |
Coordinates | 1903622..1904539 (-) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | W8UPQ8 |
Locus tag | QRA14_RS09275 | Protein ID | WP_004151732.1 |
Coordinates | 1904545..1905303 (-) | Length | 253 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QRA14_RS09250 (QRA14_09250) | 1898928..1900448 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
QRA14_RS09255 (QRA14_09255) | 1900445..1901443 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
QRA14_RS09260 (QRA14_09260) | 1901474..1902415 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
QRA14_RS09265 (QRA14_09265) | 1902490..1903497 | + | 1008 | WP_004151731.1 | carbohydrate kinase family protein | - |
QRA14_RS09270 (QRA14_09270) | 1903622..1904539 | - | 918 | WP_002885155.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
QRA14_RS09275 (QRA14_09275) | 1904545..1905303 | - | 759 | WP_004151732.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
QRA14_RS09280 (QRA14_09280) | 1905389..1906117 | - | 729 | WP_002885152.1 | response regulator transcription factor | - |
QRA14_RS09285 (QRA14_09285) | 1906390..1908537 | + | 2148 | WP_077598858.1 | formate dehydrogenase subunit alpha | - |
QRA14_RS09290 (QRA14_09290) | 1908767..1909453 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34687.15 Da Isoelectric Point: 5.4707
>T283636 WP_002885155.1 NZ_CP127229:c1904539-1903622 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28564.92 Da Isoelectric Point: 10.0870
>AT283636 WP_004151732.1 NZ_CP127229:c1905303-1904545 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GH11 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GQB5 |