283635

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1747438..1747954 Replicon chromosome
Accession NZ_CP127229
Organism Klebsiella pneumoniae strain 130119

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QRA14_RS08470 Protein ID WP_002886902.1
Coordinates 1747438..1747722 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QRA14_RS08475 Protein ID WP_002886901.1
Coordinates 1747712..1747954 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRA14_RS08445 (QRA14_08445) 1742922..1743185 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QRA14_RS08450 (QRA14_08450) 1743315..1743488 + 174 WP_002886906.1 hypothetical protein -
QRA14_RS08455 (QRA14_08455) 1743491..1744234 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QRA14_RS08460 (QRA14_08460) 1744591..1746729 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
QRA14_RS08465 (QRA14_08465) 1746970..1747434 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QRA14_RS08470 (QRA14_08470) 1747438..1747722 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRA14_RS08475 (QRA14_08475) 1747712..1747954 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QRA14_RS08480 (QRA14_08480) 1748032..1749942 - 1911 WP_004152270.1 PRD domain-containing protein -
QRA14_RS08485 (QRA14_08485) 1749965..1751119 - 1155 WP_002886900.1 lactonase family protein -
QRA14_RS08490 (QRA14_08490) 1751185..1751925 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T283635 WP_002886902.1 NZ_CP127229:c1747722-1747438 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT283635 WP_002886901.1 NZ_CP127229:c1747954-1747712 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References