Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5355802..5356429 Replicon chromosome
Accession NZ_CP127228
Organism Pseudomonas tohonis strain KRS022

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag QQ016_RS23910 Protein ID WP_263151077.1
Coordinates 5355802..5355984 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag QQ016_RS23915 Protein ID WP_263151076.1
Coordinates 5356022..5356429 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ016_RS23885 5351821..5352582 + 762 WP_111263764.1 amino acid ABC transporter ATP-binding protein -
QQ016_RS23890 5353034..5353987 - 954 WP_285960856.1 helix-turn-helix domain-containing protein -
QQ016_RS23895 5354104..5354574 + 471 WP_285960857.1 nuclear transport factor 2 family protein -
QQ016_RS23900 5354656..5355354 + 699 WP_271103913.1 glutathione S-transferase family protein -
QQ016_RS23905 5355351..5355659 + 309 WP_263151078.1 GIY-YIG nuclease family protein -
QQ016_RS23910 5355802..5355984 + 183 WP_263151077.1 type II toxin-antitoxin system HicA family toxin Toxin
QQ016_RS23915 5356022..5356429 + 408 WP_263151076.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
QQ016_RS23920 5356592..5357527 + 936 WP_285960858.1 glutathione S-transferase family protein -
QQ016_RS23925 5357585..5358592 - 1008 WP_271103910.1 nucleoid-associated protein YejK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6841.90 Da        Isoelectric Point: 10.5627

>T283630 WP_263151077.1 NZ_CP127228:5355802-5355984 [Pseudomonas tohonis]
MRSREVIEKIKEDGWYEVDVKGSHHQFKHPSKPGRVTVPHPRSDLPIGTVRSILKQAGLL

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14523.38 Da        Isoelectric Point: 4.3759

>AT283630 WP_263151076.1 NZ_CP127228:5356022-5356429 [Pseudomonas tohonis]
MKFPIVLHKDPDSDYGVTVPDVPGCFSAGATVAEALENVKEALALHFEGLVADGETLPQAQQIDVYIGNPDFAGGVWAVV
EFDVTPYLGKAVRFNATLPENLLRRIDERVGKDARYASRSGFLATAALRELSDAS

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References