Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 556720..557356 Replicon chromosome
Accession NZ_CP127223
Organism Bacillus licheniformis strain Jrh14-10

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag QQ984_RS02775 Protein ID WP_003179128.1
Coordinates 557006..557356 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag QQ984_RS02770 Protein ID WP_006638778.1
Coordinates 556720..557001 (+) Length 94 a.a.

Genomic Context

QQ984_RS02750QQ984_RS02760QQ984_RS02765QQ984_RS02770QQ984_RS02775QQ984_RS02780QQ984_RS02785QQ984_RS02790QQ984_RS02795QQ984_RS02800QQ984_RS02805QQ984_RS02810QQ984_RS02815QQ984_RS02755
Location: 551835..553316 (1482 bp)
Type: Others
Protein ID: WP_009330132.1
Location: 554255..555214 (960 bp)
Type: Others
Protein ID: WP_154495823.1
Location: 555439..556608 (1170 bp)
Type: Others
Protein ID: WP_026080763.1
Location: 556720..557001 (282 bp)
Type: Antitoxin
Protein ID: WP_006638778.1
Location: 557006..557356 (351 bp)
Type: Toxin
Protein ID: WP_003179128.1
Location: 557474..558301 (828 bp)
Type: Others
Protein ID: WP_061578564.1
Location: 558305..558670 (366 bp)
Type: Others
Protein ID: WP_003179132.1
Location: 558673..559074 (402 bp)
Type: Others
Protein ID: WP_003179135.1
Location: 559085..560092 (1008 bp)
Type: Others
Protein ID: WP_003179137.1
Location: 560151..560477 (327 bp)
Type: Others
Protein ID: WP_003179140.1
Location: 560477..560962 (486 bp)
Type: Others
Protein ID: WP_003179142.1
Location: 560928..561719 (792 bp)
Type: Others
Protein ID: WP_003179144.1
Location: 561716..562315 (600 bp)
Type: Others
Protein ID: WP_003179145.1
Location: 553313..553912 (600 bp)
Type: Others
Protein ID: WP_003179118.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
QQ984_RS02750 (QQ984_02750)551835..553316+1482WP_009330132.1PH domain-containing protein-
QQ984_RS02755 (QQ984_02755)553313..553912-600WP_003179118.1rhomboid family intramembrane serine protease-
QQ984_RS02760 (QQ984_02760)554255..555214+960WP_154495823.1outer membrane lipoprotein carrier protein LolA-
QQ984_RS02765 (QQ984_02765)555439..556608+1170WP_026080763.1alanine racemase-
QQ984_RS02770 (QQ984_02770)556720..557001+282WP_006638778.1hypothetical proteinAntitoxin
QQ984_RS02775 (QQ984_02775)557006..557356+351WP_003179128.1type II toxin-antitoxin system endoribonuclease NdoAToxin
QQ984_RS02780 (QQ984_02780)557474..558301+828WP_061578564.1RsbT co-antagonist protein RsbRA-
QQ984_RS02785 (QQ984_02785)558305..558670+366WP_003179132.1STAS domain-containing protein-
QQ984_RS02790 (QQ984_02790)558673..559074+402WP_003179135.1anti-sigma regulatory factor-
QQ984_RS02795 (QQ984_02795)559085..560092+1008WP_003179137.1PP2C family protein-serine/threonine phosphatase-
QQ984_RS02800 (QQ984_02800)560151..560477+327WP_003179140.1anti-sigma factor antagonist-
QQ984_RS02805 (QQ984_02805)560477..560962+486WP_003179142.1anti-sigma B factor RsbW-
QQ984_RS02810 (QQ984_02810)560928..561719+792WP_003179144.1RNA polymerase sigma factor SigB-
QQ984_RS02815 (QQ984_02815)561716..562315+600WP_003179145.1PP2C family serine/threonine-protein phosphatase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T283623 WP_003179128.1 NZ_CP127223:557006-557356 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT283623 WP_006638778.1 NZ_CP127223:556720-557001 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A6I7FHI4

Antitoxin

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Source
ID
Structure
AlphaFold DBM5PDU2

References