Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 556720..557356 Replicon chromosome
Accession NZ_CP127223
Organism Bacillus licheniformis strain Jrh14-10

Toxin (Protein)


Gene name mazF Uniprot ID M5P3Q9
Locus tag QQ984_RS02775 Protein ID WP_003179128.1
Coordinates 557006..557356 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID M5PDU2
Locus tag QQ984_RS02770 Protein ID WP_006638778.1
Coordinates 556720..557001 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ984_RS02750 (QQ984_02750) 551835..553316 + 1482 WP_009330132.1 PH domain-containing protein -
QQ984_RS02755 (QQ984_02755) 553313..553912 - 600 WP_003179118.1 rhomboid family intramembrane serine protease -
QQ984_RS02760 (QQ984_02760) 554255..555214 + 960 WP_154495823.1 outer membrane lipoprotein carrier protein LolA -
QQ984_RS02765 (QQ984_02765) 555439..556608 + 1170 WP_026080763.1 alanine racemase -
QQ984_RS02770 (QQ984_02770) 556720..557001 + 282 WP_006638778.1 hypothetical protein Antitoxin
QQ984_RS02775 (QQ984_02775) 557006..557356 + 351 WP_003179128.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
QQ984_RS02780 (QQ984_02780) 557474..558301 + 828 WP_061578564.1 RsbT co-antagonist protein RsbRA -
QQ984_RS02785 (QQ984_02785) 558305..558670 + 366 WP_003179132.1 STAS domain-containing protein -
QQ984_RS02790 (QQ984_02790) 558673..559074 + 402 WP_003179135.1 anti-sigma regulatory factor -
QQ984_RS02795 (QQ984_02795) 559085..560092 + 1008 WP_003179137.1 PP2C family protein-serine/threonine phosphatase -
QQ984_RS02800 (QQ984_02800) 560151..560477 + 327 WP_003179140.1 anti-sigma factor antagonist -
QQ984_RS02805 (QQ984_02805) 560477..560962 + 486 WP_003179142.1 anti-sigma B factor RsbW -
QQ984_RS02810 (QQ984_02810) 560928..561719 + 792 WP_003179144.1 RNA polymerase sigma factor SigB -
QQ984_RS02815 (QQ984_02815) 561716..562315 + 600 WP_003179145.1 PP2C family serine/threonine-protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12990.03 Da        Isoelectric Point: 5.7234

>T283623 WP_003179128.1 NZ_CP127223:557006-557356 [Bacillus licheniformis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNNIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVNEALQISLALIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10649.03 Da        Isoelectric Point: 4.6920

>AT283623 WP_006638778.1 NZ_CP127223:556720-557001 [Bacillus licheniformis]
MSESSATTEILIRLPEALVSELDGVVMQDNGSRNELIYQATKMYLRERKNRQIRESMRRGYMEMAKINLNISSEAQFAEY
EAENTVERLVSGG

Download         Length: 282 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I7FHI4

Antitoxin

Source ID Structure
AlphaFold DB M5PDU2

References