Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-DinJ
Location 34968..35502 Replicon plasmid p90_2023_B
Accession NZ_CP127179
Organism Enterococcus faecalis strain 90_2023

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag QQS48_RS13785 Protein ID WP_048948955.1
Coordinates 35227..35502 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID R3H6P0
Locus tag QQS48_RS13780 Protein ID WP_002369771.1
Coordinates 34968..35234 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQS48_RS13735 (QQS48_13735) 30429..30590 + 162 WP_002399271.1 hypothetical protein -
QQS48_RS13740 (QQS48_13740) 30587..31372 + 786 WP_002387611.1 replication-relaxation family protein -
QQS48_RS13745 (QQS48_13745) 31378..31866 + 489 WP_002404733.1 hypothetical protein -
QQS48_RS13750 (QQS48_13750) 32459..32725 + 267 WP_126266275.1 hypothetical protein -
QQS48_RS13755 (QQS48_13755) 32758..33258 + 501 WP_002360775.1 DnaJ domain-containing protein -
QQS48_RS13760 (QQS48_13760) 33395..33520 + 126 WP_229023520.1 DUF3850 domain-containing protein -
QQS48_RS13765 (QQS48_13765) 33596..34012 + 417 WP_126266276.1 single-stranded DNA-binding protein -
QQS48_RS13770 (QQS48_13770) 34036..34620 + 585 WP_126266277.1 thermonuclease family protein -
QQS48_RS13775 (QQS48_13775) 34617..34865 + 249 WP_126266278.1 alpha-glucosidase -
QQS48_RS13780 (QQS48_13780) 34968..35234 + 267 WP_002369771.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QQS48_RS13785 (QQS48_13785) 35227..35502 + 276 WP_048948955.1 type II toxin-antitoxin system YafQ family toxin Toxin
QQS48_RS13790 (QQS48_13790) 36305..36490 + 186 WP_002365983.1 hypothetical protein -
QQS48_RS13795 (QQS48_13795) 36475..36666 + 192 WP_002399282.1 DpnD/PcfM family protein -
QQS48_RS13800 (QQS48_13800) 36690..37241 + 552 WP_126263907.1 hypothetical protein -
QQS48_RS13805 (QQS48_13805) 37376..38155 + 780 WP_126266279.1 Cas9 inhibitor AcrIIA9 family protein -
QQS48_RS13810 (QQS48_13810) 38155..39498 + 1344 WP_126267491.1 PcfJ domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid fexA prgB/asc10 1..62024 62024


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(7-87)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10718.55 Da        Isoelectric Point: 9.6918

>T283622 WP_048948955.1 NZ_CP127179:35227-35502 [Enterococcus faecalis]
MLEIFYTNQFKKDFKKAKKQGKNLEKLKDVLVLLQEQQTLPPKYKDHALTGNYIGTRECHIEPDWLLIYKIDGDKLILTL
ARIGSHSELFR

Download         Length: 276 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9804.15 Da        Isoelectric Point: 4.4791

>AT283622 WP_002369771.1 NZ_CP127179:34968-35234 [Enterococcus faecalis]
MATTKKKPIHVNVDENLKEEAEQLFDDLGLNMTSAITIFLKQSINEQAIPFMINKGNKETLQALKDIKEGNVHGGFSSVE
DLMEDLNA

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AED7

References