283620

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 69939..71047 Replicon plasmid p90_2023_A
Accession NZ_CP127178
Organism Enterococcus faecalis strain 90_2023

Toxin (Protein)


Gene name MNTss Uniprot ID -
Locus tag QQS48_RS13440 Protein ID WP_078126936.1
Coordinates 69939..70808 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag QQS48_RS13445 Protein ID WP_002303393.1
Coordinates 70823..71047 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQS48_RS13405 (QQS48_13405) 65370..66107 - 738 WP_001038796.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
QQS48_RS13410 (QQS48_13410) 66232..66315 - 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
QQS48_RS13415 (QQS48_13415) 66364..66447 - 84 Protein_77 MLS leader peptide -
QQS48_RS13420 (QQS48_13420) 66857..67651 - 795 WP_001096887.1 aminoglycoside O-phosphotransferase APH(3')-IIIa -
QQS48_RS13425 (QQS48_13425) 67744..68286 - 543 WP_000627290.1 streptothricin N-acetyltransferase Sat4 -
QQS48_RS13430 (QQS48_13430) 68283..69191 - 909 WP_001255866.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
QQS48_RS13435 (QQS48_13435) 69224..69958 - 735 WP_000662263.1 class I SAM-dependent methyltransferase -
QQS48_RS13440 (QQS48_13440) 69939..70808 - 870 WP_078126936.1 nucleotidyltransferase domain-containing protein Toxin
QQS48_RS13445 (QQS48_13445) 70823..71047 - 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
QQS48_RS13450 (QQS48_13450) 71190..72011 - 822 Protein_84 recombinase zinc beta ribbon domain-containing protein -
QQS48_RS13455 (QQS48_13455) 72699..73502 - 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
QQS48_RS13460 (QQS48_13460) 73556..75040 - 1485 WP_002294513.1 ABC-F type ribosomal protection protein Lsa(E) -
QQS48_RS13465 (QQS48_13465) 75483..76046 - 564 Protein_87 recombinase zinc beta ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid cat / tet(L) / tet(M) / erm(B) / aph(3')-III / ant(6)-Ia / lnu(B) / lsa(E) / aac(6')-aph(2'') / dfrG - 1..92098 92098
- inside IS/Tn erm(B) / aph(3')-III / ant(6)-Ia / lnu(B) / lsa(E) / aac(6')-aph(2'') / dfrG - 65370..89778 24408


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32835.43 Da        Isoelectric Point: 4.7269

>T283620 WP_078126936.1 NZ_CP127178:c70808-69939 [Enterococcus faecalis]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT283620 WP_002303393.1 NZ_CP127178:c71047-70823 [Enterococcus faecalis]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References