Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907(toxin) |
Location | 58763..59334 | Replicon | plasmid p90_2023_A |
Accession | NZ_CP127178 | ||
Organism | Enterococcus faecalis strain 90_2023 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | A0A2Z2CGM4 |
Locus tag | QQS48_RS13335 | Protein ID | WP_002362432.1 |
Coordinates | 58763..59104 (-) | Length | 114 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | R3KHK9 |
Locus tag | QQS48_RS13340 | Protein ID | WP_002362431.1 |
Coordinates | 59104..59334 (-) | Length | 77 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QQS48_RS13310 (QQS48_13310) | 53780..54472 | - | 693 | WP_033918847.1 | Fic family protein | - |
QQS48_RS13315 (QQS48_13315) | 54521..55120 | - | 600 | WP_008382128.1 | tyrosine-type recombinase/integrase | - |
QQS48_RS13325 (QQS48_13325) | 56846..57448 | - | 603 | WP_002362434.1 | Fic family protein | - |
QQS48_RS13330 (QQS48_13330) | 57713..58651 | - | 939 | WP_002362433.1 | hypothetical protein | - |
QQS48_RS13335 (QQS48_13335) | 58763..59104 | - | 342 | WP_002362432.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
QQS48_RS13340 (QQS48_13340) | 59104..59334 | - | 231 | WP_002362431.1 | hypothetical protein | Antitoxin |
QQS48_RS13345 (QQS48_13345) | 59538..60158 | + | 621 | WP_002367784.1 | recombinase family protein | - |
QQS48_RS13350 (QQS48_13350) | 60148..60462 | + | 315 | WP_002367785.1 | hypothetical protein | - |
QQS48_RS13355 (QQS48_13355) | 60456..60662 | + | 207 | WP_002367786.1 | hypothetical protein | - |
QQS48_RS13360 (QQS48_13360) | 60822..61016 | + | 195 | WP_002367787.1 | hypothetical protein | - |
QQS48_RS13365 (QQS48_13365) | 61028..61219 | + | 192 | WP_002367788.1 | hypothetical protein | - |
QQS48_RS13370 (QQS48_13370) | 61389..61604 | + | 216 | WP_002367791.1 | leucocin A/sakacin P family class II bacteriocin | - |
QQS48_RS13375 (QQS48_13375) | 61605..61946 | + | 342 | WP_002367792.1 | bacteriocin immunity protein | - |
QQS48_RS13380 (QQS48_13380) | 62362..62880 | + | 519 | WP_002367793.1 | hypothetical protein | - |
QQS48_RS13385 (QQS48_13385) | 62828..63043 | + | 216 | WP_002415356.1 | hypothetical protein | - |
QQS48_RS13390 (QQS48_13390) | 63135..63221 | + | 87 | WP_012881081.1 | type I toxin-antitoxin system Fst family toxin | - |
QQS48_RS13395 (QQS48_13395) | 63478..63774 | + | 297 | WP_002367795.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | cat / tet(L) / tet(M) / erm(B) / aph(3')-III / ant(6)-Ia / lnu(B) / lsa(E) / aac(6')-aph(2'') / dfrG | - | 1..92098 | 92098 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 114 a.a. Molecular weight: 13244.44 Da Isoelectric Point: 8.0113
>T283619 WP_002362432.1 NZ_CP127178:c59104-58763 [Enterococcus faecalis]
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEHLPLKDMAKIDQIIEYIF
MSDEKKYIPKKGDIVWIDFDPSAEKEIQKRRPGLVVSRYEFNRKTLFAVICPITSTIKNMPTRYTLPDEMETHGQVVISQ
LKSLDFAERKLSQIEHLPLKDMAKIDQIIEYIF
Download Length: 342 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2Z2CGM4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | R3KHK9 |