Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2628292..2628863 Replicon chromosome
Accession NZ_CP127177
Organism Enterococcus faecalis strain 90_2023

Toxin (Protein)


Gene name mazF Uniprot ID R3GRA7
Locus tag QQS48_RS12490 Protein ID WP_002360937.1
Coordinates 2628292..2628633 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3JGB1
Locus tag QQS48_RS12495 Protein ID WP_002354773.1
Coordinates 2628633..2628863 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQS48_RS12485 (2624307) 2624307..2627921 - 3615 WP_002389470.1 DNA-directed RNA polymerase subunit beta -
QQS48_RS12490 (2628292) 2628292..2628633 - 342 WP_002360937.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QQS48_RS12495 (2628633) 2628633..2628863 - 231 WP_002354773.1 hypothetical protein Antitoxin
QQS48_RS12500 (2629037) 2629037..2629252 - 216 WP_002354768.1 zinc ribbon domain-containing protein -
QQS48_RS12505 (2629391) 2629391..2630383 + 993 WP_002358973.1 biotin--[acetyl-CoA-carboxylase] ligase -
QQS48_RS12510 (2630450) 2630450..2631082 - 633 WP_002358972.1 RloB family protein -
QQS48_RS12515 (2631091) 2631091..2632386 - 1296 WP_002371641.1 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13165.41 Da        Isoelectric Point: 9.3988

>T283612 WP_002360937.1 NZ_CP127177:c2628633-2628292 [Enterococcus faecalis]
MNVEKKYIPKKGDIVWIDFDPAAGKEIQKRRPGLVVSRYEFNRKTMFAVICPITSTIKNIPTRYTLPDDIETHGQVVISQ
LKSLDFTERKLSQIEHLPLKDMAKIDQIIEYIF

Download         Length: 342 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8677.67 Da        Isoelectric Point: 4.3313

>AT283612 WP_002354773.1 NZ_CP127177:c2628863-2628633 [Enterococcus faecalis]
MLTTKSRRQGSSVVLTLPTDNGKKPKVDQEYIVMYSDDGTITLVPKIQDPFSEGPEGEYYEKDEWHDLAPEGRELF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M2A7G9

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2A812

References