283606

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1240998..1241915 Replicon chromosome
Accession NZ_CP127164
Organism Bacillus velezensis strain B14

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag QQ974_RS06485 Protein ID WP_007407256.1
Coordinates 1241169..1241915 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag QQ974_RS06480 Protein ID WP_003154807.1
Coordinates 1240998..1241168 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ974_RS06440 (QQ974_06440) 1236231..1237853 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
QQ974_RS06445 (QQ974_06445) 1237866..1238237 + 372 WP_032874603.1 XkdW family protein -
QQ974_RS06450 (QQ974_06450) 1238242..1238439 + 198 WP_032874605.1 XkdX family protein -
QQ974_RS06455 (QQ974_06455) 1238496..1239257 + 762 WP_032874607.1 hypothetical protein -
QQ974_RS06460 (QQ974_06460) 1239309..1239572 + 264 WP_003154815.1 hemolysin XhlA family protein -
QQ974_RS06465 (QQ974_06465) 1239586..1239849 + 264 WP_003154813.1 phage holin -
QQ974_RS06470 (QQ974_06470) 1239863..1240741 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
QQ974_RS06475 (QQ974_06475) 1240776..1240901 - 126 WP_003154809.1 hypothetical protein -
QQ974_RS06480 (QQ974_06480) 1240998..1241168 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QQ974_RS06485 (QQ974_06485) 1241169..1241915 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QQ974_RS06490 (QQ974_06490) 1242020..1243018 - 999 WP_032874611.1 inorganic phosphate transporter -
QQ974_RS06495 (QQ974_06495) 1243031..1243648 - 618 WP_032874614.1 DUF47 domain-containing protein -
QQ974_RS06500 (QQ974_06500) 1243934..1245250 - 1317 WP_032874616.1 amino acid permease -
QQ974_RS06505 (QQ974_06505) 1245572..1246522 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T283606 WP_007407256.1 NZ_CP127164:c1241915-1241169 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT283606 WP_003154807.1 NZ_CP127164:c1241168-1240998 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References