283602

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) omega-epsilon-zeta/epsilon(antitoxin)
Location 792656..793061 Replicon chromosome
Accession NZ_CP127160
Organism Enterococcus sp. FZMF

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag QN079_RS03885 Protein ID WP_289230401.1
Coordinates 792930..793061 (+) Length 44 a.a.

Antitoxin (Protein)


Gene name epsilon Uniprot ID Q9AL19
Locus tag QN079_RS03880 Protein ID WP_002326825.1
Coordinates 792656..792928 (+) Length 91 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN079_RS03840 (QN079_03840) 788568..788969 - 402 WP_160160814.1 protein rep -
QN079_RS03845 (QN079_03845) 789005..789535 + 531 Protein_761 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
QN079_RS03850 (QN079_03850) 789669..789908 + 240 WP_000635249.1 peptide-binding protein -
QN079_RS03855 (QN079_03855) 789957..790040 + 84 WP_001814874.1 23S rRNA methyltransferase attenuation leader peptide -
QN079_RS03860 (QN079_03860) 790165..790902 + 738 WP_001038795.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) -
QN079_RS03865 (QN079_03865) 791072..791332 + 261 Protein_765 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
QN079_RS03870 (QN079_03870) 791435..792331 + 897 WP_289230400.1 ParA family protein -
QN079_RS03875 (QN079_03875) 792423..792638 + 216 WP_001835296.1 peptide-binding protein -
QN079_RS03880 (QN079_03880) 792656..792928 + 273 WP_002326825.1 antitoxin Antitoxin
QN079_RS03885 (QN079_03885) 792930..793061 + 132 WP_289230401.1 hypothetical protein Toxin
QN079_RS03890 (QN079_03890) 793115..793795 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
QN079_RS03895 (QN079_03895) 794120..794287 - 168 WP_005228365.1 cysteine-rich KTR domain-containing protein -
QN079_RS03900 (QN079_03900) 794375..796315 - 1941 WP_002405437.1 tetracycline resistance ribosomal protection protein Tet(S) -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element ant(6)-Ia / tet(L) / erm(B) / tet(S) - 777294..803302 26008
- inside IScluster/Tn ant(6)-Ia / tet(L) / erm(B) / tet(S) - 778902..799455 20553


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(2-90)


Sequences


Toxin        


Download         Length: 44 a.a.        Molecular weight: 4945.63 Da        Isoelectric Point: 6.2182

>T283602 WP_289230401.1 NZ_CP127160:792930-793061 [Enterococcus sp. FZMF]
MANITDFTEKQFEDRLEKNVERLTKNRLAVESPTAFLGSVAKF

Download         Length: 132 bp


Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10720.17 Da        Isoelectric Point: 4.4865

>AT283602 WP_002326825.1 NZ_CP127160:792656-792928 [Enterococcus sp. FZMF]
MAVTYEKTFEIEIINELSASVYNRVLNYVLNHELDTKNTRLLEVNLLNQLEVAQEVDLFQQPFEELQAIHEYWRSMNQYS
KQILTKEKVA

Download         Length: 273 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0M2AF93

References