283601

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 777046..778154 Replicon chromosome
Accession NZ_CP127160
Organism Enterococcus sp. FZMF

Toxin (Protein)


Gene name MNTss Uniprot ID R3JIN1
Locus tag QN079_RS03790 Protein ID WP_000233000.1
Coordinates 777285..778154 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID -
Locus tag QN079_RS03785 Protein ID WP_000205227.1
Coordinates 777046..777270 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN079_RS03765 (QN079_03765) 773374..773907 + 534 WP_289230397.1 GrpB family protein -
QN079_RS03770 (QN079_03770) 773941..774388 + 448 Protein_746 CatB-related O-acetyltransferase -
QN079_RS03775 (QN079_03775) 774704..775456 + 753 WP_289230398.1 hypothetical protein -
QN079_RS03780 (QN079_03780) 776181..776903 + 723 Protein_748 zinc ribbon domain-containing protein -
QN079_RS03785 (QN079_03785) 777046..777270 + 225 WP_000205227.1 helix-turn-helix transcriptional regulator Antitoxin
QN079_RS03790 (QN079_03790) 777285..778154 + 870 WP_000233000.1 nucleotidyltransferase domain-containing protein Toxin
QN079_RS03795 (QN079_03795) 778135..778869 + 735 WP_000662263.1 class I SAM-dependent methyltransferase -
QN079_RS03800 (QN079_03800) 778902..779765 + 864 WP_002294505.1 aminoglycoside nucleotidyltransferase ANT(6)-Ia -
QN079_RS03805 (QN079_03805) 779852..781042 - 1191 WP_289230399.1 IS256-like element ISLgar5 family transposase -
QN079_RS03810 (QN079_03810) 781153..781680 + 528 WP_002294507.1 phosphoribosyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32926.57 Da        Isoelectric Point: 4.8781

>T283601 WP_000233000.1 NZ_CP127160:777285-778154 [Enterococcus sp. FZMF]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARGTHTENSDIDIGIYYNSDSFDLTAINQIATELDDKNRNNLVVPPGAWGDW
INGGGWLFINGYHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGVEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8365.68 Da        Isoelectric Point: 4.5510

>AT283601 WP_000205227.1 NZ_CP127160:777046-777270 [Enterococcus sp. FZMF]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGEEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3JIN1

Antitoxin

Source ID Structure

References