283599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 661..1135 Replicon plasmid pT1_p5
Accession NZ_CP127158
Organism Klebsiella pneumoniae subsp. pneumoniae strain T1

Toxin (Protein)


Gene name pasB Uniprot ID A0A8J3DT22
Locus tag QP513_RS29985 Protein ID WP_004197762.1
Coordinates 869..1135 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID S1EJF5
Locus tag QP513_RS29980 Protein ID WP_000879771.1
Coordinates 661..885 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP513_RS29980 (QP513_29980) 661..885 + 225 WP_000879771.1 DUF6290 family protein Antitoxin
QP513_RS29985 (QP513_29985) 869..1135 + 267 WP_004197762.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP513_RS29990 (QP513_29990) 1205..1555 - 351 WP_149795812.1 hypothetical protein -
QP513_RS29995 (QP513_29995) 1621..2166 - 546 WP_023317533.1 hypothetical protein -
QP513_RS30000 (QP513_30000) 2192..2518 - 327 WP_050516389.1 hypothetical protein -
QP513_RS30005 (QP513_30005) 3674..3850 + 177 WP_004197757.1 hypothetical protein -
QP513_RS30010 (QP513_30010) 3840..4184 + 345 WP_062955149.1 MobC family plasmid mobilization relaxosome protein -
QP513_RS30015 (QP513_30015) 4393..4827 + 435 Protein_7 relaxase/mobilization nuclease domain-containing protein -
QP513_RS30020 (QP513_30020) 4862..5371 + 510 WP_032433972.1 MbeB family mobilization protein -
QP513_RS30025 (QP513_30025) 5378..5590 + 213 WP_021527181.1 MbeD family mobilization/exclusion protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - - 1..5596 5596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

Relaxosome protein TraY

(4-45)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10342.96 Da        Isoelectric Point: 9.8727

>T283599 WP_004197762.1 NZ_CP127158:869-1135 [Klebsiella pneumoniae subsp. pneumoniae]
MVWTINYSDRALKSLRKMDKQNARRIVDFMSLRIAVAADPRQSGKPLKGELGEFWRYRVGDYRVLCEIRDDELVILAATI
GHRREVYD

Download         Length: 267 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8369.28 Da        Isoelectric Point: 4.6533

>AT283599 WP_000879771.1 NZ_CP127158:661-885 [Klebsiella pneumoniae subsp. pneumoniae]
MLAIRLSDEIESRLDSLAKQTGRTKTFYAREAILAHLEDLEDYYLSAETAARVRRGDEAVHSSEDVRKSLGLDD

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB S1EJF5

References