Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 3418..3998 Replicon plasmid pT1_p4
Accession NZ_CP127157
Organism Klebsiella pneumoniae subsp. pneumoniae strain T1

Toxin (Protein)


Gene name parE Uniprot ID A0A8J3DTL7
Locus tag QP513_RS29935 Protein ID WP_071177730.1
Coordinates 3418..3732 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X1PRM1
Locus tag QP513_RS29940 Protein ID WP_000093040.1
Coordinates 3720..3998 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP513_RS29915 (QP513_29915) 1326..2057 + 732 WP_071177728.1 MobC family replication-relaxation protein -
QP513_RS29920 (QP513_29920) 2064..2594 + 531 WP_071177729.1 hypothetical protein -
QP513_RS29925 (QP513_29925) 2621..2800 - 180 WP_000165970.1 Rop family plasmid primer RNA-binding protein -
QP513_RS29930 (QP513_29930) 2826..3254 - 429 WP_001140599.1 hypothetical protein -
QP513_RS29935 (QP513_29935) 3418..3732 - 315 WP_071177730.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP513_RS29940 (QP513_29940) 3720..3998 - 279 WP_000093040.1 CopG family ribbon-helix-helix protein Antitoxin
QP513_RS29945 (QP513_29945) 4173..4538 - 366 WP_072354022.1 TonB family protein -
QP513_RS29950 (QP513_29950) 4535..4906 - 372 WP_001237044.1 cell envelope integrity protein TolA -
QP513_RS29955 (QP513_29955) 5180..5425 - 246 WP_032440458.1 hypothetical protein -
QP513_RS29960 (QP513_29960) 6070..7557 + 1488 WP_004178082.1 group II intron reverse transcriptase/maturase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..11971 11971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-96)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11805.73 Da        Isoelectric Point: 9.8324

>T283598 WP_071177730.1 NZ_CP127157:c3732-3418 [Klebsiella pneumoniae subsp. pneumoniae]
MPQVTISALAQRDLQRLQDFLKTKNRLAARKGGEVIVRAIQQLKTLPDIGRPVPFLPLEYKELVIGFGDSGYVMLYRHDR
EMDQIVIVTVRHQKESGYPGADSL

Download         Length: 315 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10709.73 Da        Isoelectric Point: 4.7561

>AT283598 WP_000093040.1 NZ_CP127157:c3998-3720 [Klebsiella pneumoniae subsp. pneumoniae]
MSSATSIRLDEELKDRLKTLADDRHRSAHALMLEAITEYIDREEKRSQYLRDGQAAWQHYQETGLHLTAEEAEAWISTWG
TENEQDAPPCHR

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2X1PRM1

References