Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4941346..4941862 Replicon chromosome
Accession NZ_CP127153
Organism Klebsiella pneumoniae subsp. pneumoniae strain T1

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QP513_RS24700 Protein ID WP_002886902.1
Coordinates 4941346..4941630 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QP513_RS24705 Protein ID WP_002886901.1
Coordinates 4941620..4941862 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP513_RS24675 (QP513_24675) 4936830..4937093 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
QP513_RS24680 (QP513_24680) 4937223..4937396 + 174 WP_002886906.1 hypothetical protein -
QP513_RS24685 (QP513_24685) 4937399..4938142 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QP513_RS24690 (QP513_24690) 4938499..4940637 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
QP513_RS24695 (QP513_24695) 4940878..4941342 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QP513_RS24700 (QP513_24700) 4941346..4941630 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP513_RS24705 (QP513_24705) 4941620..4941862 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QP513_RS24710 (QP513_24710) 4941940..4943850 - 1911 WP_004152270.1 PRD domain-containing protein -
QP513_RS24715 (QP513_24715) 4943873..4945027 - 1155 WP_002886900.1 lactonase family protein -
QP513_RS24720 (QP513_24720) 4945093..4945833 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T283587 WP_002886902.1 NZ_CP127153:c4941630-4941346 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT283587 WP_002886901.1 NZ_CP127153:c4941862-4941620 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References