Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4838752..4839562 Replicon chromosome
Accession NZ_CP127153
Organism Klebsiella pneumoniae subsp. pneumoniae strain T1

Toxin (Protein)


Gene name KacT Uniprot ID A0A0H3GMP0
Locus tag QP513_RS24215 Protein ID WP_002887280.1
Coordinates 4838752..4839285 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag QP513_RS24220 Protein ID WP_002887278.1
Coordinates 4839296..4839562 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP513_RS24210 (QP513_24210) 4837583..4838704 + 1122 WP_002887282.1 cupin domain-containing protein -
QP513_RS24215 (QP513_24215) 4838752..4839285 - 534 WP_002887280.1 type II toxin-antitoxin system toxin KacT Toxin
QP513_RS24220 (QP513_24220) 4839296..4839562 - 267 WP_002887278.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QP513_RS24225 (QP513_24225) 4839665..4841098 - 1434 WP_002887275.1 Cu(+)/Ag(+) sensor histidine kinase -
QP513_RS24230 (QP513_24230) 4841088..4841771 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QP513_RS24235 (QP513_24235) 4841943..4843328 + 1386 WP_002887267.1 efflux transporter outer membrane subunit -
QP513_RS24240 (QP513_24240) 4843346..4843690 + 345 WP_002887266.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19838.70 Da        Isoelectric Point: 5.2614

>T283586 WP_002887280.1 NZ_CP127153:c4839285-4838752 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHVMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT283586 WP_002887278.1 NZ_CP127153:c4839562-4839296 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5ZGN
PDB 5XUN

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References