Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2759383..2760971 Replicon chromosome
Accession NZ_CP127153
Organism Klebsiella pneumoniae subsp. pneumoniae strain T1

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag QP513_RS13855 Protein ID WP_004199851.1
Coordinates 2759383..2760705 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag QP513_RS13860 Protein ID WP_002904790.1
Coordinates 2760705..2760971 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP513_RS13840 (QP513_13840) 2754448..2756949 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
QP513_RS13845 (QP513_13845) 2756937..2757941 + 1005 WP_004199852.1 fimbrial protein -
QP513_RS13850 (QP513_13850) 2758074..2759366 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QP513_RS13855 (QP513_13855) 2759383..2760705 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
QP513_RS13860 (QP513_13860) 2760705..2760971 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QP513_RS13865 (QP513_13865) 2761237..2761563 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QP513_RS13870 (QP513_13870) 2761560..2762060 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QP513_RS13875 (QP513_13875) 2762038..2763417 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
QP513_RS13880 (QP513_13880) 2763763..2764917 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QP513_RS13885 (QP513_13885) 2764898..2765821 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T283584 WP_004199851.1 NZ_CP127153:c2760705-2759383 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT283584 WP_002904790.1 NZ_CP127153:c2760971-2760705 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References