Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 875938..876592 Replicon chromosome
Accession NZ_CP127153
Organism Klebsiella pneumoniae subsp. pneumoniae strain T1

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag QP513_RS04420 Protein ID WP_004144731.1
Coordinates 876185..876592 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QP513_RS04415 Protein ID WP_002916312.1
Coordinates 875938..876204 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP513_RS04390 (QP513_04390) 871094..872527 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QP513_RS04395 (QP513_04395) 872646..873374 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QP513_RS04400 (QP513_04400) 873424..873735 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
QP513_RS04405 (QP513_04405) 873899..874558 + 660 WP_002916317.1 hemolysin III family protein -
QP513_RS04410 (QP513_04410) 874709..875692 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QP513_RS04415 (QP513_04415) 875938..876204 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QP513_RS04420 (QP513_04420) 876185..876592 + 408 WP_004144731.1 protein YgfX Toxin
QP513_RS04425 (QP513_04425) 876599..877120 - 522 WP_002916308.1 flavodoxin FldB -
QP513_RS04430 (QP513_04430) 877221..878117 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QP513_RS04435 (QP513_04435) 878140..878853 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QP513_RS04440 (QP513_04440) 878859..880592 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T283579 WP_004144731.1 NZ_CP127153:876185-876592 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT283579 WP_002916312.1 NZ_CP127153:875938-876204 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References