283573

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3585304..3586524 Replicon chromosome
Accession NZ_CP127126
Organism Pseudomonas aeruginosa PA14 strain MA3 isolate DTU_MIE

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag P4A98_RS16475 Protein ID WP_003110488.1
Coordinates 3585946..3586524 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag P4A98_RS16470 Protein ID WP_003088112.1
Coordinates 3585304..3585858 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P4A98_RS16445 (P4A98_16445) 3580872..3581423 + 552 WP_003139878.1 XRE family transcriptional regulator -
P4A98_RS16450 (P4A98_16450) 3581420..3581818 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
P4A98_RS16455 (P4A98_16455) 3581831..3582154 - 324 WP_003102734.1 multidrug efflux SMR transporter -
P4A98_RS16460 (P4A98_16460) 3582485..3582946 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
P4A98_RS16465 (P4A98_16465) 3582951..3585146 + 2196 WP_003139882.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
P4A98_RS16470 (P4A98_16470) 3585304..3585858 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
P4A98_RS16475 (P4A98_16475) 3585946..3586524 + 579 WP_003110488.1 HD domain-containing protein Toxin
P4A98_RS16480 (P4A98_16480) 3586633..3587820 - 1188 WP_003139884.1 HlyD family efflux transporter periplasmic adaptor subunit -
P4A98_RS16485 (P4A98_16485) 3587810..3589981 - 2172 WP_003139887.1 type I secretion system permease/ATPase -
P4A98_RS16490 (P4A98_16490) 3589971..3591248 - 1278 WP_003139889.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T283573 WP_003110488.1 NZ_CP127126:3585946-3586524 [Pseudomonas aeruginosa PA14]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T283573 NZ_CP127126:3585946-3586524 [Pseudomonas aeruginosa PA14]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAAGCCGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCATCTGGACAC
GCCGCTGCGCGATCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGACCGCCGAAGCCCTGGCAGTGAAAGCGC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGTTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT283573 WP_003088112.1 NZ_CP127126:3585304-3585858 [Pseudomonas aeruginosa PA14]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT283573 NZ_CP127126:3585304-3585858 [Pseudomonas aeruginosa PA14]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCTTGCTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCCCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References