Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2192268..2192784 Replicon chromosome
Accession NZ_CP127114
Organism Pseudomonas sp. M2(2023)

Toxin (Protein)


Gene name relE Uniprot ID F8G1E7
Locus tag QN085_RS10190 Protein ID WP_003259987.1
Coordinates 2192503..2192784 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8G1E6
Locus tag QN085_RS10185 Protein ID WP_013972043.1
Coordinates 2192268..2192513 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QN085_RS10165 (QN085_10165) 2187695..2188237 - 543 WP_013972039.1 WYL domain-containing protein -
QN085_RS10170 (QN085_10170) 2188345..2189331 - 987 WP_013972040.1 zinc-binding dehydrogenase -
QN085_RS10175 (QN085_10175) 2189694..2190887 + 1194 WP_023662327.1 MFS transporter -
QN085_RS10180 (QN085_10180) 2190918..2192024 + 1107 WP_031325095.1 alkene reductase -
QN085_RS10185 (QN085_10185) 2192268..2192513 + 246 WP_013972043.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QN085_RS10190 (QN085_10190) 2192503..2192784 + 282 WP_003259987.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QN085_RS10195 (QN085_10195) 2192823..2193218 - 396 WP_023662326.1 hypothetical protein -
QN085_RS10200 (QN085_10200) 2193307..2194215 - 909 WP_013972045.1 LysR family transcriptional regulator -
QN085_RS10205 (QN085_10205) 2194445..2195749 + 1305 WP_013972046.1 MFS transporter -
QN085_RS10210 (QN085_10210) 2195780..2197021 + 1242 WP_013972047.1 Zn-dependent hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10909.78 Da        Isoelectric Point: 10.7594

>T283567 WP_003259987.1 NZ_CP127114:2192503-2192784 [Pseudomonas sp. M2(2023)]
MTYKLEFLPSALKEWGKLGHTVREQIKKKLAERLQSPKVQADALRDLPNHYKIKLKASGYRLVYRVEDERIVVVVVSVGK
RERSEVYRSAQKR

Download         Length: 282 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8779.21 Da        Isoelectric Point: 4.3611

>AT283567 WP_013972043.1 NZ_CP127114:2192268-2192513 [Pseudomonas sp. M2(2023)]
MQNIFADVAVSVSELKKNPSAVMTGAAGMPVAVLNHNRVMGYMVPAELYEAMMERLEDLELSELAKSRLGEKGVPVSLDD
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F8G1E7

Antitoxin

Source ID Structure
AlphaFold DB F8G1E6

References