Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 827373..827897 Replicon chromosome
Accession NZ_CP127101
Organism Staphylococcus pseudintermedius strain 10916-77753

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag QQZ06_RS03730 Protein ID WP_014613379.1
Coordinates 827544..827897 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag QQZ06_RS03725 Protein ID WP_014613378.1
Coordinates 827373..827543 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQZ06_RS03700 (QQZ06_03700) 823262..823735 + 474 WP_063279122.1 PH domain-containing protein -
QQZ06_RS03705 (QQZ06_03705) 823728..825257 + 1530 WP_063279121.1 PH domain-containing protein -
QQZ06_RS03710 (QQZ06_03710) 825241..825759 + 519 WP_014613375.1 PH domain-containing protein -
QQZ06_RS03715 (QQZ06_03715) 825756..826106 + 351 WP_063279120.1 holo-ACP synthase -
QQZ06_RS03720 (QQZ06_03720) 826140..827288 + 1149 WP_014613377.1 alanine racemase -
QQZ06_RS03725 (QQZ06_03725) 827373..827543 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QQZ06_RS03730 (QQZ06_03730) 827544..827897 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QQZ06_RS03735 (QQZ06_03735) 827955..828959 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
QQZ06_RS03740 (QQZ06_03740) 829038..829364 + 327 WP_014613381.1 anti-sigma factor antagonist -
QQZ06_RS03745 (QQZ06_03745) 829364..829843 + 480 WP_031253870.1 anti-sigma B factor RsbW -
QQZ06_RS03750 (QQZ06_03750) 829818..830588 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T283565 WP_014613379.1 NZ_CP127101:827544-827897 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT283565 WP_014613378.1 NZ_CP127101:827373-827543 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References