Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 812457..812978 Replicon chromosome
Accession NZ_CP127101
Organism Staphylococcus pseudintermedius strain 10916-77753

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag QQZ06_RS03655 Protein ID WP_014613364.1
Coordinates 812757..812978 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag QQZ06_RS03650 Protein ID WP_014613363.1
Coordinates 812457..812744 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQZ06_RS03625 (QQZ06_03625) 807718..808521 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
QQZ06_RS03630 (QQZ06_03630) 808511..809149 + 639 WP_063284943.1 thiamine phosphate synthase -
QQZ06_RS03635 (QQZ06_03635) 809238..810104 + 867 WP_014613360.1 membrane protein insertase YidC -
QQZ06_RS03640 (QQZ06_03640) 810158..810814 - 657 WP_014613361.1 HD domain-containing protein -
QQZ06_RS03645 (QQZ06_03645) 810835..812325 - 1491 WP_099986639.1 cardiolipin synthase -
QQZ06_RS03650 (QQZ06_03650) 812457..812744 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
QQZ06_RS03655 (QQZ06_03655) 812757..812978 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
QQZ06_RS03660 (QQZ06_03660) 812982..813188 + 207 WP_014613365.1 cation transporter -
QQZ06_RS03665 (QQZ06_03665) 813289..815469 + 2181 WP_063279127.1 heavy metal translocating P-type ATPase -
QQZ06_RS03670 (QQZ06_03670) 815555..815701 + 147 WP_014613367.1 Lmo0850 family protein -
QQZ06_RS03675 (QQZ06_03675) 816669..817397 + 729 WP_014613368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T283564 WP_014613364.1 NZ_CP127101:812757-812978 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT283564 WP_014613363.1 NZ_CP127101:812457-812744 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References