283562

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 852240..852764 Replicon chromosome
Accession NZ_CP127100
Organism Staphylococcus pseudintermedius strain 6127-64107

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag QQZ05_RS03780 Protein ID WP_014613379.1
Coordinates 852411..852764 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag QQZ05_RS03775 Protein ID WP_014613378.1
Coordinates 852240..852410 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQZ05_RS03750 (QQZ05_03750) 848129..848602 + 474 WP_014613373.1 PH domain-containing protein -
QQZ05_RS03755 (QQZ05_03755) 848595..850124 + 1530 WP_099997491.1 PH domain-containing protein -
QQZ05_RS03760 (QQZ05_03760) 850108..850626 + 519 WP_014613375.1 PH domain-containing protein -
QQZ05_RS03765 (QQZ05_03765) 850623..850973 + 351 WP_014613376.1 holo-ACP synthase -
QQZ05_RS03770 (QQZ05_03770) 851007..852155 + 1149 WP_014613377.1 alanine racemase -
QQZ05_RS03775 (QQZ05_03775) 852240..852410 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QQZ05_RS03780 (QQZ05_03780) 852411..852764 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QQZ05_RS03785 (QQZ05_03785) 852822..853826 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
QQZ05_RS03790 (QQZ05_03790) 853905..854231 + 327 WP_014613381.1 anti-sigma factor antagonist -
QQZ05_RS03795 (QQZ05_03795) 854231..854710 + 480 WP_031253870.1 anti-sigma B factor RsbW -
QQZ05_RS03800 (QQZ05_03800) 854685..855455 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T283562 WP_014613379.1 NZ_CP127100:852411-852764 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT283562 WP_014613378.1 NZ_CP127100:852240-852410 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References