283561

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 837324..837845 Replicon chromosome
Accession NZ_CP127100
Organism Staphylococcus pseudintermedius strain 6127-64107

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag QQZ05_RS03705 Protein ID WP_014613364.1
Coordinates 837624..837845 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag QQZ05_RS03700 Protein ID WP_014613363.1
Coordinates 837324..837611 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQZ05_RS03675 (QQZ05_03675) 832585..833388 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
QQZ05_RS03680 (QQZ05_03680) 833378..834016 + 639 WP_014613359.1 thiamine phosphate synthase -
QQZ05_RS03685 (QQZ05_03685) 834105..834971 + 867 WP_014613360.1 membrane protein insertase YidC -
QQZ05_RS03690 (QQZ05_03690) 835025..835681 - 657 WP_014613361.1 HD domain-containing protein -
QQZ05_RS03695 (QQZ05_03695) 835702..837192 - 1491 WP_065520420.1 cardiolipin synthase -
QQZ05_RS03700 (QQZ05_03700) 837324..837611 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
QQZ05_RS03705 (QQZ05_03705) 837624..837845 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
QQZ05_RS03710 (QQZ05_03710) 837849..838055 + 207 WP_014613365.1 cation transporter -
QQZ05_RS03715 (QQZ05_03715) 838156..840336 + 2181 WP_063279127.1 heavy metal translocating P-type ATPase -
QQZ05_RS03720 (QQZ05_03720) 840422..840568 + 147 WP_014613367.1 Lmo0850 family protein -
QQZ05_RS03725 (QQZ05_03725) 841536..842264 + 729 WP_014613368.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T283561 WP_014613364.1 NZ_CP127100:837624-837845 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT283561 WP_014613363.1 NZ_CP127100:837324-837611 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References