Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 922079..922611 Replicon chromosome
Accession NZ_CP127096
Organism Staphylococcus haemolyticus strain M1691_10

Toxin (Protein)


Gene name mazF Uniprot ID Q4L7V3
Locus tag QQO14_RS04570 Protein ID WP_011275272.1
Coordinates 922246..922611 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A2K0A6Q6
Locus tag QQO14_RS04565 Protein ID WP_037538759.1
Coordinates 922079..922249 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO14_RS04540 917865..918344 + 480 WP_285491378.1 PH domain-containing protein -
QQO14_RS04545 918337..919860 + 1524 WP_285491380.1 PH domain-containing protein -
QQO14_RS04550 919853..920380 + 528 WP_285491383.1 PH domain-containing protein -
QQO14_RS04555 920390..920749 + 360 WP_011275269.1 holo-ACP synthase -
QQO14_RS04560 920845..921993 + 1149 WP_285491385.1 alanine racemase -
QQO14_RS04565 922079..922249 + 171 WP_037538759.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QQO14_RS04570 922246..922611 + 366 WP_011275272.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QQO14_RS04575 922919..923920 + 1002 WP_285491386.1 PP2C family protein-serine/threonine phosphatase -
QQO14_RS04580 924019..924345 + 327 WP_285491388.1 anti-sigma factor antagonist -
QQO14_RS04585 924374..924826 + 453 WP_285491725.1 anti-sigma B factor RsbW -
QQO14_RS04590 924801..925571 + 771 WP_285491390.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13672.75 Da        Isoelectric Point: 8.4121

>T283556 WP_011275272.1 NZ_CP127096:922246-922611 [Staphylococcus haemolyticus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYRLDKDSVILLEQIR
TLDKKRLKEKLTYLSDEKMQEVDEALDISLGLHDEVKTQNT

Download         Length: 366 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6380.08 Da        Isoelectric Point: 4.0325

>AT283556 WP_037538759.1 NZ_CP127096:922079-922249 [Staphylococcus haemolyticus]
MLTFNQNRSHSLEQSLKEGYAQMAELNLSLATEAFPLECEACDCNETYIISNYKSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A1KA75

Antitoxin

Source ID Structure
AlphaFold DB A0A2K0A6Q6

References