283552

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 942225..942749 Replicon chromosome
Accession NZ_CP127094
Organism Staphylococcus pseudintermedius strain 19KM0990

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag QQO15_RS04335 Protein ID WP_014613379.1
Coordinates 942396..942749 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag QQO15_RS04330 Protein ID WP_014613378.1
Coordinates 942225..942395 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO15_RS04305 (QQO15_04305) 938114..938587 + 474 WP_014613373.1 PH domain-containing protein -
QQO15_RS04310 (QQO15_04310) 938580..940109 + 1530 WP_105503167.1 PH domain-containing protein -
QQO15_RS04315 (QQO15_04315) 940093..940611 + 519 WP_014613375.1 PH domain-containing protein -
QQO15_RS04320 (QQO15_04320) 940608..940958 + 351 WP_014613376.1 holo-ACP synthase -
QQO15_RS04325 (QQO15_04325) 940992..942140 + 1149 WP_014613377.1 alanine racemase -
QQO15_RS04330 (QQO15_04330) 942225..942395 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
QQO15_RS04335 (QQO15_04335) 942396..942749 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QQO15_RS04340 (QQO15_04340) 942807..943811 + 1005 WP_014613380.1 PP2C family protein-serine/threonine phosphatase -
QQO15_RS04345 (QQO15_04345) 943890..944216 + 327 WP_014613381.1 anti-sigma factor antagonist -
QQO15_RS04350 (QQO15_04350) 944216..944695 + 480 WP_031253870.1 anti-sigma B factor RsbW -
QQO15_RS04355 (QQO15_04355) 944670..945440 + 771 WP_015729428.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T283552 WP_014613379.1 NZ_CP127094:942396-942749 [Staphylococcus pseudintermedius]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT283552 WP_014613378.1 NZ_CP127094:942225-942395 [Staphylococcus pseudintermedius]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References