Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 927158..927679 Replicon chromosome
Accession NZ_CP127094
Organism Staphylococcus pseudintermedius strain 19KM0990

Toxin (Protein)


Gene name TsdT Uniprot ID A0A3D8YLE8
Locus tag QQO15_RS04260 Protein ID WP_014613364.1
Coordinates 927458..927679 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A166R1D0
Locus tag QQO15_RS04255 Protein ID WP_014613363.1
Coordinates 927158..927445 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO15_RS04230 (QQO15_04230) 922419..923222 + 804 WP_014613358.1 hydroxyethylthiazole kinase -
QQO15_RS04235 (QQO15_04235) 923212..923850 + 639 WP_285238547.1 thiamine phosphate synthase -
QQO15_RS04240 (QQO15_04240) 923939..924805 + 867 WP_014613360.1 membrane protein insertase YidC -
QQO15_RS04245 (QQO15_04245) 924859..925515 - 657 WP_014613361.1 HD domain-containing protein -
QQO15_RS04250 (QQO15_04250) 925536..927026 - 1491 WP_014613362.1 cardiolipin synthase -
QQO15_RS04255 (QQO15_04255) 927158..927445 + 288 WP_014613363.1 copper-sensing transcriptional repressor CsoR Antitoxin
QQO15_RS04260 (QQO15_04260) 927458..927679 + 222 WP_014613364.1 heavy metal-associated domain-containing protein Toxin
QQO15_RS04265 (QQO15_04265) 927683..927889 + 207 WP_014613365.1 cation transporter -
QQO15_RS04270 (QQO15_04270) 927990..930170 + 2181 WP_015729432.1 heavy metal translocating P-type ATPase -
QQO15_RS04275 (QQO15_04275) 930256..930402 + 147 WP_014613367.1 Lmo0850 family protein -
QQO15_RS04280 (QQO15_04280) 931521..932249 + 729 WP_194178557.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(3-93)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8065.10 Da        Isoelectric Point: 4.3480

>T283551 WP_014613364.1 NZ_CP127094:927458-927679 [Staphylococcus pseudintermedius]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVAIDVATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Download         Length: 222 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10997.59 Da        Isoelectric Point: 7.0504

>AT283551 WP_014613363.1 NZ_CP127094:927158-927445 [Staphylococcus pseudintermedius]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIKHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D8YLE8

Antitoxin

Source ID Structure
AlphaFold DB A0A166R1D0

References