Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/HicA(toxin) |
Location | 304342..304981 | Replicon | chromosome |
Accession | NZ_CP127045 | ||
Organism | Pseudomonas amygdali pv. lachrymans strain YM7902 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A7Z6Y3C5 |
Locus tag | QO021_RS01380 | Protein ID | WP_005781617.1 |
Coordinates | 304342..304524 (+) | Length | 61 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | A0A0Q0DRU8 |
Locus tag | QO021_RS01385 | Protein ID | WP_016981256.1 |
Coordinates | 304556..304981 (+) | Length | 142 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
QO021_RS01345 (QO021_01345) | 299703..300296 | + | 594 | WP_002551454.1 | imidazoleglycerol-phosphate dehydratase HisB | - |
QO021_RS01350 (QO021_01350) | 300296..300934 | + | 639 | WP_005745046.1 | imidazole glycerol phosphate synthase subunit HisH | - |
QO021_RS01355 (QO021_01355) | 300939..301199 | + | 261 | WP_002551456.1 | DUF2164 domain-containing protein | - |
QO021_RS01360 (QO021_01360) | 301307..302044 | + | 738 | WP_002551457.1 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase | - |
QO021_RS01365 (QO021_01365) | 302064..302834 | + | 771 | WP_002551458.1 | imidazole glycerol phosphate synthase subunit HisF | - |
QO021_RS01370 (QO021_01370) | 303020..303775 | + | 756 | WP_004663214.1 | ABC transporter substrate-binding protein | - |
QO021_RS01375 (QO021_01375) | 303780..304020 | - | 241 | Protein_271 | serine protease | - |
QO021_RS01380 (QO021_01380) | 304342..304524 | + | 183 | WP_005781617.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
QO021_RS01385 (QO021_01385) | 304556..304981 | + | 426 | WP_016981256.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
QO021_RS01390 (QO021_01390) | 305036..305818 | - | 783 | WP_005745049.1 | divergent polysaccharide deacetylase family protein | - |
QO021_RS01395 (QO021_01395) | 305822..307165 | - | 1344 | WP_005745050.1 | S41 family peptidase | - |
QO021_RS01400 (QO021_01400) | 307199..308521 | - | 1323 | WP_029240926.1 | murein hydrolase activator EnvC | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6877.97 Da Isoelectric Point: 10.6211
>T283545 WP_005781617.1 NZ_CP127045:304342-304524 [Pseudomonas amygdali pv. lachrymans]
MKCNEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD
MKCNEFRRWLQAQGAEFRAAKGSHFKVYLNGKATIFADHGSKEMHEGLRKSIIKQLGLKD
Download Length: 183 bp
Antitoxin
Download Length: 142 a.a. Molecular weight: 15783.24 Da Isoelectric Point: 5.2548
>AT283545 WP_016981256.1 NZ_CP127045:304556-304981 [Pseudomonas amygdali pv. lachrymans]
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA
MYQYPLDLHREPTGVWLSCPDIPEMSASGDTLPEAFSEALDGMESALSLYVDQRRKIPQASVVPGHELLMRLPALTVAKI
MLWNSLLEEGVSRAELARRLGCTRQVVDRLVDFLHASKIEQVERALAELGRRITLSIERAA
Download Length: 426 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7Z6Y3C5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0Q0DRU8 |