Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2364234..2364748 Replicon chromosome
Accession NZ_CP127024
Organism Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-048_8421A

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QQO08_RS11970 Protein ID WP_000581792.1
Coordinates 2364234..2364443 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QQO08_RS11975 Protein ID WP_000138932.1
Coordinates 2364455..2364748 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO08_RS11950 (QQO08_11950) 2359742..2361100 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QQO08_RS11955 (QQO08_11955) 2361115..2362185 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
QQO08_RS11960 (QQO08_11960) 2362503..2363705 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
QQO08_RS11965 (QQO08_11965) 2363969..2364106 - 138 WP_000828354.1 Lmo0850 family protein -
QQO08_RS11970 (QQO08_11970) 2364234..2364443 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QQO08_RS11975 (QQO08_11975) 2364455..2364748 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QQO08_RS11980 (QQO08_11980) 2364914..2366398 + 1485 WP_000571549.1 cardiolipin synthase -
QQO08_RS11985 (QQO08_11985) 2366426..2367073 + 648 WP_001187629.1 HD domain-containing protein -
QQO08_RS11990 (QQO08_11990) 2367886..2368758 - 873 WP_000725802.1 membrane protein insertase YidC -
QQO08_RS11995 (QQO08_11995) 2368844..2369485 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T283539 WP_000581792.1 NZ_CP127024:c2364443-2364234 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT283539 WP_000138932.1 NZ_CP127024:c2364748-2364455 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References