Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2409812..2410326 Replicon chromosome
Accession NZ_CP127019
Organism Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-009_371M

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag QQO11_RS12325 Protein ID WP_000581792.1
Coordinates 2409812..2410021 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag QQO11_RS12330 Protein ID WP_000138932.1
Coordinates 2410033..2410326 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO11_RS12305 (2405320) 2405320..2406678 - 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
QQO11_RS12310 (2406693) 2406693..2407763 - 1071 WP_285236797.1 D-alanine--D-alanine ligase -
QQO11_RS12315 (2408081) 2408081..2409283 + 1203 WP_285236798.1 FtsW/RodA/SpoVE family cell cycle protein -
QQO11_RS12320 (2409547) 2409547..2409684 - 138 WP_000828354.1 Lmo0850 family protein -
QQO11_RS12325 (2409812) 2409812..2410021 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
QQO11_RS12330 (2410033) 2410033..2410326 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
QQO11_RS12335 (2410492) 2410492..2411976 + 1485 WP_000571549.1 cardiolipin synthase -
QQO11_RS12340 (2412004) 2412004..2412651 + 648 WP_001187629.1 HD domain-containing protein -
QQO11_RS12345 (2413464) 2413464..2414336 - 873 WP_000725802.1 membrane protein insertase YidC -
QQO11_RS12350 (2414422) 2414422..2415063 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T283508 WP_000581792.1 NZ_CP127019:c2410021-2409812 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT283508 WP_000138932.1 NZ_CP127019:c2410326-2410033 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References