Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2061477..2062253 Replicon chromosome
Accession NZ_CP127019
Organism Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-009_371M

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QQO11_RS10210 Protein ID WP_000031108.1
Coordinates 2061477..2061629 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QQO11_RS10215 Protein ID WP_001251224.1
Coordinates 2061654..2062253 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO11_RS10195 (2057439) 2057439..2058260 + 822 WP_000669375.1 RluA family pseudouridine synthase -
QQO11_RS10200 (2058723) 2058723..2060108 - 1386 WP_000116224.1 class II fumarate hydratase -
QQO11_RS10205 (2060304) 2060304..2060699 - 396 WP_000901021.1 hypothetical protein -
QQO11_RS10210 (2061477) 2061477..2061629 - 153 WP_000031108.1 SAS053 family protein Toxin
QQO11_RS10215 (2061654) 2061654..2062253 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QQO11_RS10220 (2062412) 2062412..2062882 - 471 WP_285236779.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QQO11_RS10225 (2062887) 2062887..2064014 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
QQO11_RS10230 (2064165) 2064165..2064887 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QQO11_RS10235 (2064880) 2064880..2066337 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T283501 WP_000031108.1 NZ_CP127019:c2061629-2061477 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT283501 WP_001251224.1 NZ_CP127019:c2062253-2061654 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References