Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1894907..1895683 Replicon chromosome
Accession NZ_CP127017
Organism Staphylococcus aureus strain CC8-MSSA (PVL+) isolate Trinidad&Tobago_2020-042_7641M

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag QQO09_RS09210 Protein ID WP_000031108.1
Coordinates 1894907..1895059 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag QQO09_RS09215 Protein ID WP_001251224.1
Coordinates 1895084..1895683 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQO09_RS09195 (1890870) 1890870..1891691 + 822 WP_000669376.1 RluA family pseudouridine synthase -
QQO09_RS09200 (1892154) 1892154..1893539 - 1386 WP_000116224.1 class II fumarate hydratase -
QQO09_RS09205 (1893735) 1893735..1894130 - 396 WP_000901021.1 hypothetical protein -
QQO09_RS09210 (1894907) 1894907..1895059 - 153 WP_000031108.1 SAS053 family protein Toxin
QQO09_RS09215 (1895084) 1895084..1895683 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
QQO09_RS09220 (1895842) 1895842..1896312 - 471 WP_000181398.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
QQO09_RS09225 (1896317) 1896317..1897444 - 1128 WP_000379978.1 tRNA epoxyqueuosine(34) reductase QueG -
QQO09_RS09230 (1897595) 1897595..1898317 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
QQO09_RS09235 (1898310) 1898310..1899767 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T283485 WP_000031108.1 NZ_CP127017:c1895059-1894907 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT283485 WP_001251224.1 NZ_CP127017:c1895683-1895084 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References