Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 4901756..4903437 | Replicon | chromosome |
| Accession | NZ_CP126987 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain T3 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A6TH06 |
| Locus tag | QP573_RS23755 | Protein ID | WP_015959269.1 |
| Coordinates | 4901756..4902631 (-) | Length | 292 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A6TH05 |
| Locus tag | QP573_RS23760 | Protein ID | WP_004177809.1 |
| Coordinates | 4902679..4903437 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QP573_RS23735 (4897062) | 4897062..4898582 | + | 1521 | WP_002885173.1 | sugar ABC transporter ATP-binding protein | - |
| QP573_RS23740 (4898579) | 4898579..4899577 | + | 999 | WP_002885172.1 | ribose ABC transporter permease | - |
| QP573_RS23745 (4899608) | 4899608..4900549 | + | 942 | WP_002885156.1 | ABC transporter substrate-binding protein | - |
| QP573_RS23750 (4900624) | 4900624..4901631 | + | 1008 | WP_015959270.1 | carbohydrate kinase family protein | - |
| QP573_RS23755 (4901756) | 4901756..4902631 | - | 876 | WP_015959269.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| QP573_RS23760 (4902679) | 4902679..4903437 | - | 759 | WP_004177809.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| QP573_RS23765 (4903523) | 4903523..4904251 | - | 729 | WP_032413197.1 | response regulator transcription factor | - |
| QP573_RS23770 (4904524) | 4904524..4906671 | + | 2148 | WP_012737173.1 | formate dehydrogenase H subunit alpha, selenocysteine-containing | - |
| QP573_RS23775 (4907249) | 4907249..4907935 | + | 687 | WP_004151733.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 292 a.a. Molecular weight: 32990.17 Da Isoelectric Point: 5.4637
>T283463 WP_015959269.1 NZ_CP126987:c4902631-4901756 [Klebsiella pneumoniae subsp. pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 876 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28548.92 Da Isoelectric Point: 10.0870
>AT283463 WP_004177809.1 NZ_CP126987:c4903437-4902679 [Klebsiella pneumoniae subsp. pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|