Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1470745..1471481 Replicon chromosome
Accession NZ_CP126987
Organism Klebsiella pneumoniae subsp. pneumoniae strain T3

Toxin (Protein)


Gene name tacT Uniprot ID A0A4S4Y1H2
Locus tag QP573_RS07270 Protein ID WP_032433360.1
Coordinates 1470999..1471481 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QP573_RS07265 Protein ID WP_003026799.1
Coordinates 1470745..1471011 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP573_RS07240 (1466391) 1466391..1467530 + 1140 WP_032433368.1 mannitol dehydrogenase -
QP573_RS07245 (1467559) 1467559..1468221 + 663 WP_032433366.1 dihydroxyacetone kinase subunit DhaL -
QP573_RS07250 (1468202) 1468202..1469209 + 1008 WP_280954017.1 dihydroxyacetone kinase subunit DhaK -
QP573_RS07255 (1469227) 1469227..1469859 + 633 WP_032433362.1 3-hexulose-6-phosphate synthase -
QP573_RS07260 (1469869) 1469869..1470432 + 564 WP_032433361.1 6-phospho-3-hexuloisomerase -
QP573_RS07265 (1470745) 1470745..1471011 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QP573_RS07270 (1470999) 1470999..1471481 + 483 WP_032433360.1 GNAT family N-acetyltransferase Toxin
QP573_RS07275 (1471639) 1471639..1473171 - 1533 WP_015065592.1 IS3-like element ISKpn38 family transposase -
QP573_RS07280 (1473283) 1473283..1474686 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
QP573_RS07285 (1474715) 1474715..1475347 - 633 WP_001567369.1 hypothetical protein -
QP573_RS07290 (1475727) 1475727..1476326 - 600 WP_032432064.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1438690..1486309 47619


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(72-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17421.02 Da        Isoelectric Point: 9.6047

>T283454 WP_032433360.1 NZ_CP126987:1470999-1471481 [Klebsiella pneumoniae subsp. pneumoniae]
VGRVTAPEPLSSSHQLAEFVSGETVLDEWLKHRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTETTGRLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT283454 WP_003026799.1 NZ_CP126987:1470745-1471011 [Klebsiella pneumoniae subsp. pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4S4Y1H2

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References