Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 834297..834954 Replicon chromosome
Accession NZ_CP126987
Organism Klebsiella pneumoniae subsp. pneumoniae strain T3

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QP573_RS04185 Protein ID WP_002916310.1
Coordinates 834544..834954 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QP573_RS04180 Protein ID WP_002916312.1
Coordinates 834297..834563 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP573_RS04155 (829453) 829453..830886 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
QP573_RS04160 (831005) 831005..831733 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QP573_RS04165 (831783) 831783..832094 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QP573_RS04170 (832258) 832258..832917 + 660 WP_002916317.1 hemolysin III family protein -
QP573_RS04175 (833068) 833068..834051 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QP573_RS04180 (834297) 834297..834563 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QP573_RS04185 (834544) 834544..834954 + 411 WP_002916310.1 protein YgfX Toxin
QP573_RS04190 (834961) 834961..835482 - 522 WP_004144730.1 flavodoxin FldB -
QP573_RS04195 (835583) 835583..836479 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QP573_RS04200 (836502) 836502..837215 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QP573_RS04205 (837221) 837221..838954 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T283452 WP_002916310.1 NZ_CP126987:834544-834954 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT283452 WP_002916312.1 NZ_CP126987:834297-834563 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References