Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1079891..1080808 Replicon chromosome
Accession NZ_CP126986
Organism Bacillus velezensis strain MC2S-6

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag QQF37_RS05545 Protein ID WP_007407256.1
Coordinates 1080062..1080808 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag QQF37_RS05540 Protein ID WP_003154807.1
Coordinates 1079891..1080061 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQF37_RS05500 (QQF37_05500) 1075124..1076746 + 1623 WP_032874601.1 pyocin knob domain-containing protein -
QQF37_RS05505 (QQF37_05505) 1076759..1077130 + 372 WP_032874603.1 XkdW family protein -
QQF37_RS05510 (QQF37_05510) 1077135..1077332 + 198 WP_032874605.1 XkdX family protein -
QQF37_RS05515 (QQF37_05515) 1077389..1078150 + 762 WP_032874607.1 hypothetical protein -
QQF37_RS05520 (QQF37_05520) 1078202..1078465 + 264 WP_003154815.1 hemolysin XhlA family protein -
QQF37_RS05525 (QQF37_05525) 1078479..1078742 + 264 WP_003154813.1 phage holin -
QQF37_RS05530 (QQF37_05530) 1078756..1079634 + 879 WP_032874609.1 N-acetylmuramoyl-L-alanine amidase -
QQF37_RS05535 (QQF37_05535) 1079669..1079794 - 126 WP_003154809.1 hypothetical protein -
QQF37_RS05540 (QQF37_05540) 1079891..1080061 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
QQF37_RS05545 (QQF37_05545) 1080062..1080808 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
QQF37_RS05550 (QQF37_05550) 1080913..1081911 - 999 WP_032874611.1 inorganic phosphate transporter -
QQF37_RS05555 (QQF37_05555) 1081924..1082541 - 618 WP_032874614.1 DUF47 domain-containing protein -
QQF37_RS05560 (QQF37_05560) 1082827..1084143 - 1317 WP_032874616.1 amino acid permease -
QQF37_RS05565 (QQF37_05565) 1084465..1085415 + 951 WP_032874618.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T283449 WP_007407256.1 NZ_CP126986:c1080808-1080062 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT283449 WP_003154807.1 NZ_CP126986:c1080061-1079891 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References