Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 1517304..1517818 Replicon chromosome
Accession NZ_CP126980
Organism Actinoplanes sp. NRRL 3884

Toxin (Protein)


Gene name relB Uniprot ID -
Locus tag Actob_RS07100 Protein ID WP_284919258.1
Coordinates 1517304..1517564 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag Actob_RS07105 Protein ID WP_284919259.1
Coordinates 1517561..1517818 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Actob_RS07075 (ACTOB_001415) 1512950..1513390 - 441 WP_284919253.1 hypothetical protein -
Actob_RS07080 (ACTOB_001416) 1513813..1514136 - 324 WP_284919254.1 toxin-antitoxin system HicB family antitoxin -
Actob_RS07085 (ACTOB_001417) 1514139..1514390 - 252 WP_284919255.1 toxin HicA -
Actob_RS07090 (ACTOB_001418) 1514858..1516087 + 1230 WP_284919256.1 hypothetical protein -
Actob_RS07095 (ACTOB_001419) 1516145..1517281 + 1137 WP_284919257.1 hypothetical protein -
Actob_RS07100 (ACTOB_001420) 1517304..1517564 - 261 WP_284919258.1 Txe/YoeB family addiction module toxin Toxin
Actob_RS07105 (ACTOB_001421) 1517561..1517818 - 258 WP_284919259.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
Actob_RS07110 (ACTOB_001422) 1518091..1518405 + 315 WP_284919260.1 hypothetical protein -
Actob_RS07115 (ACTOB_001423) 1518402..1519541 + 1140 WP_284919261.1 hypothetical protein -
Actob_RS07120 (ACTOB_001424) 1519589..1520239 + 651 WP_284919262.1 hypothetical protein -
Actob_RS07125 (ACTOB_001425) 1520259..1522397 - 2139 WP_284919263.1 glycosyl hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1508914..1520239 11325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(4-70)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10241.56 Da        Isoelectric Point: 7.2750

>T283445 WP_284919258.1 NZ_CP126980:c1517564-1517304 [Actinoplanes sp. NRRL 3884]
VKLSWTDHGWDDYLYWQTQDRKTLKRINALIADIKRDPDGQGIGKPEILRNNLAGLRSRRIDDEHRMVYAVEPNEITIIS
CRYHYE

Download         Length: 261 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9578.66 Da        Isoelectric Point: 5.1373

>AT283445 WP_284919259.1 NZ_CP126980:c1517818-1517561 [Actinoplanes sp. NRRL 3884]
VTSAISASEARKSLFPLIERVNEDHTPIEIVSKRGNAVLVSKEDWDSIMETNYLLRSPANARHLAESVEQWRAGRATQRD
FGPEE

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References