Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 1855755..1856433 Replicon chromosome
Accession NZ_CP126978
Organism Gallibacterium anatis strain YJ922

Toxin (Protein)


Gene name relE Uniprot ID F4HBW4
Locus tag QP019_RS09060 Protein ID WP_013746373.1
Coordinates 1856050..1856433 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag QP019_RS09055 Protein ID WP_013746372.1
Coordinates 1855755..1856057 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP019_RS09045 (QP019_09045) 1854191..1854907 + 717 WP_285097078.1 amino acid ABC transporter permease -
QP019_RS09050 (QP019_09050) 1854910..1855653 + 744 WP_285097079.1 amino acid ABC transporter ATP-binding protein -
QP019_RS09055 (QP019_09055) 1855755..1856057 - 303 WP_013746372.1 DNA-binding transcriptional regulator Antitoxin
QP019_RS09060 (QP019_09060) 1856050..1856433 - 384 WP_013746373.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QP019_RS09065 (QP019_09065) 1856715..1857011 + 297 WP_018346511.1 HigA family addiction module antitoxin -
QP019_RS09070 (QP019_09070) 1857042..1857629 - 588 WP_018346512.1 Fic family protein -
QP019_RS09075 (QP019_09075) 1857598..1857789 - 192 WP_013746378.1 antitoxin VbhA family protein -
QP019_RS09080 (QP019_09080) 1858164..1859543 - 1380 WP_285096077.1 cysteine--tRNA ligase -
QP019_RS09085 (QP019_09085) 1859682..1860194 + 513 WP_013746381.1 peptidylprolyl isomerase -
QP019_RS09090 (QP019_09090) 1860625..1861236 + 612 WP_285096078.1 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-88)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14213.20 Da        Isoelectric Point: 8.9256

>T283444 WP_013746373.1 NZ_CP126978:c1856433-1856050 [Gallibacterium anatis]
MRIFKTKAFNKFALKNGIPDSELINAITRAEQGLIDADLGGNIIKQRIARKGQGRSGGFRSFIFYCIQNNSYFVAGISKN
DRENISSQELAALKALAREYTRLTAKQIEAQIENGLFIEILPEAEDE

Download         Length: 384 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11270.16 Da        Isoelectric Point: 7.3581

>AT283444 WP_013746372.1 NZ_CP126978:c1856057-1855755 [Gallibacterium anatis]
MSELLAMIHENAADLHKAGIINKKTMKEFDQLCLTPVVTYTPDEIRAIREKEQVSQAVFAHYLNVSKNMISEWERGVKKP
SGAALKLLNLVQHNGIEILV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F4HBW4

Antitoxin

Source ID Structure

References