Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1290995..1291641 Replicon chromosome
Accession NZ_CP126978
Organism Gallibacterium anatis strain YJ922

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag QP019_RS06415 Protein ID WP_039081346.1
Coordinates 1290995..1291402 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0A2Z0K5
Locus tag QP019_RS06420 Protein ID WP_021461268.1
Coordinates 1291402..1291641 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QP019_RS06400 (QP019_06400) 1286701..1288746 + 2046 WP_285097073.1 methionine--tRNA ligase -
QP019_RS06405 (QP019_06405) 1288827..1289831 + 1005 WP_285095836.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
QP019_RS06410 (QP019_06410) 1290255..1290857 + 603 WP_285095837.1 transposase -
QP019_RS06415 (QP019_06415) 1290995..1291402 - 408 WP_039081346.1 tRNA(fMet)-specific endonuclease VapC Toxin
QP019_RS06420 (QP019_06420) 1291402..1291641 - 240 WP_021461268.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QP019_RS06425 (QP019_06425) 1291932..1292927 + 996 WP_285095838.1 thiamine ABC transporter substrate binding subunit -
QP019_RS06430 (QP019_06430) 1292903..1294525 + 1623 WP_285095839.1 thiamine/thiamine pyrophosphate ABC transporter permease -
QP019_RS06435 (QP019_06435) 1294512..1295174 + 663 WP_021461271.1 thiamine ABC transporter ATP-binding protein -
QP019_RS06440 (QP019_06440) 1295214..1296224 + 1011 WP_285095840.1 biotin synthase BioB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15016.54 Da        Isoelectric Point: 7.2412

>T283443 WP_039081346.1 NZ_CP126978:c1291402-1290995 [Gallibacterium anatis]
MLKYMLDTNIVIFTIKNKPPHLLPLFNENQSMLCISSITLMELVYGAEKSKKTAQNLAVIESFCARLAVLDYDEAAAYHS
GQIRAELAKIGQPIGPYDAMIAGHARSLGLTVVTNNMNEFSRVEGLRVIDWSKPM

Download         Length: 408 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9043.25 Da        Isoelectric Point: 4.4013

>AT283443 WP_021461268.1 NZ_CP126978:c1291641-1291402 [Gallibacterium anatis]
MSVVTATVFMNNKSQAIRIPKAAELPNTTKSVNIIIQGDMRIITPLNNVWDSWFNDSNSVSDDFMLSREQPQMQEREEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2Z0K5

References